State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China.
University of the Chinese Academy of Sciences, Beijing, 100049, China.
Adv Mater. 2020 Dec;32(48):e2005912. doi: 10.1002/adma.202005912. Epub 2020 Oct 30.
Functionalization of hydrogen-bonded organic frameworks (HOFs) for specific applications has been a long-lasting challenge in HOF materials. Here, an efficient way to integrate functional species in the HOF structure through constructing an anionic framework is presented. The obtained HOFs, taking PFC-33 (PFC = porous materials from FJIRSM,CAS) as an example, integrate a porphyrin photosensitizer as a porous backbone and a commercial biocide as counterions in the structure. The permanent channels and the electrostatic interaction between the framework and the counterions provide PFC-33 ion-responsive biocide-release behavior in various physiological environments, thus exhibiting synergistic photodynamic and chemical antimicrobial efficiency. The unbonded carboxyl groups residing on the HOF surface further allow for manipulating the interfacial interaction between the PFC-33 and the polymer matrix for membrane fabrication. Therefore, a polyHOF membrane with high stability, desired flexibility, and good permeability is obtained, which demonstrates noticeable bacterial inhibition toward Escherichia coli. This study may shed light on the functionalization of HOF materials for broad application potentials.
功能化氢键有机骨架（HOFs）以应用于特定领域一直是 HOF 材料的长期挑战。在这里，提出了一种通过构建阴离子骨架将功能物种有效集成到 HOF 结构中的方法。以 PFC-33（PFC = 来自 FJIRSM 的多孔材料，CAS）为例，所获得的 HOF 将卟啉类光敏剂作为多孔骨架和商业杀生剂作为结构中的抗衡离子整合在一起。永久通道和骨架与抗衡离子之间的静电相互作用使 PFC-33 在各种生理环境下表现出离子响应型杀生剂释放行为，从而表现出协同的光动力和化学抗菌效率。位于 HOF 表面的未键合的羧基基团进一步允许控制 PFC-33 和聚合物基质之间的界面相互作用，以用于膜的制造。因此，获得了具有高稳定性、所需柔韧性和良好渗透性的聚 HOF 膜，其对大肠杆菌表现出明显的抑菌作用。本研究可能为 HOF 材料的功能化提供新的思路，以拓展其广泛的应用潜力。
