Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou, Guangdong 510080, P.R. China.
Int J Mol Med. 2020 Dec;46(6):1943-1950. doi: 10.3892/ijmm.2020.4763. Epub 2020 Oct 21.
The transcription factor PU.1, an important member of the ETS family, plays a significant role in the differentiation of immune cells, which include macrophages, neutrophils, dendritic cells, T lymphoid cells, B lymphoid cells and so on. Immune cells are involved in the occurrence and development of diseases, including inflammatory diseases, neoplastic diseases and immune diseases. Therefore, it is particularly crucial to elucidate the roles and mechanisms of PU.1 in immune cells. The elucidation of these mechanisms may lead to the development of more effective therapeutic strategies for the treatment of inflammatory diseases and immune‑mediated diseases mediated by various immune cells. With the development of molecular biology, the mechanisms of PU.1 in immune cell differentiation have been further explained. Different levels of PU.1 expression determine the type of immune cell differentiation. PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews and discusses the effects of the transcription factor PU.1 on immune cell differentiation.
转录因子 PU.1 是 ETS 家族的重要成员，在免疫细胞的分化中发挥着重要作用，包括巨噬细胞、中性粒细胞、树突状细胞、T 淋巴细胞、B 淋巴细胞等。免疫细胞参与疾病的发生和发展，包括炎症性疾病、肿瘤性疾病和免疫性疾病。因此，阐明 PU.1 在免疫细胞中的作用和机制尤为重要。阐明这些机制可能会导致开发出更有效的治疗策略，以治疗由各种免疫细胞介导的炎症性疾病和免疫介导的疾病。随着分子生物学的发展，PU.1 在免疫细胞分化中的机制得到了进一步的解释。不同水平的 PU.1 表达决定了免疫细胞分化的类型。在粒细胞和巨噬细胞分化过程中，PU.1 的表达增加，而在 T 淋巴细胞和 B 淋巴细胞分化过程中，PU.1 的表达减少。本研究综述并讨论了转录因子 PU.1 对免疫细胞分化的影响。
