Centre for Computational Medicine, Hospital for Sick Children, Toronto, ON, Canada.
VIB Bioinformatics Core, Ghent, Belgium.
Methods Mol Biol. 2021;2199:191-207. doi: 10.1007/978-1-0716-0892-0_12.
iRefWeb is a resource that provides web interface to a large collection of protein-protein interactions aggregated from major primary databases. The underlying data-consolidation process, called iRefIndex, implements a rigorous methodology of identifying redundant protein sequences and integrating disparate data records that reference the same peptide sequences, despite many potential differences in data identifiers across various source databases. iRefWeb offers a unified user interface to all interaction records and associated information collected by iRefIndex, in addition to a number of data filters and visual features that present the supporting evidence. Users of iRefWeb can explore the consolidated landscape of protein-protein interactions, establish the provenance and reliability of each data record, and compare annotations performed by different data curator teams. The iRefWeb portal is freely available at http://wodaklab.org/iRefWeb .
iRefWeb 是一个资源，提供了一个网络界面，可以访问从主要原始数据库中聚合的大量蛋白质-蛋白质相互作用。底层的数据整合过程称为 iRefIndex，它采用了一种严格的方法，用于识别冗余的蛋白质序列，并整合引用相同肽序列的不同数据记录，尽管在不同来源的数据库中，数据标识符可能存在许多潜在差异。iRefWeb 为 iRefIndex 收集的所有相互作用记录和相关信息提供了一个统一的用户界面，此外还提供了一些数据筛选器和可视化功能，以展示支持证据。iRefWeb 的用户可以探索蛋白质-蛋白质相互作用的综合情况，确定每个数据记录的来源和可靠性，并比较不同数据管理员团队执行的注释。iRefWeb 门户可免费在 http://wodaklab.org/iRefWeb 获得。
