Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), Essen, Germany.
Institute of Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany.
Mol Immunol. 2020 Dec;128:116-124. doi: 10.1016/j.molimm.2020.10.011. Epub 2020 Oct 27.
In this review we introduce the basic principles of epigenetic gene regulation and discuss them in the context of dendritic cell (DC) development and differentiation. Epigenetic mechanisms control the accessibility of chromatin for DNA binding proteins and thus they control gene expression. These mechanisms comprise chemical modifications of DNA and histones, chromatin remodeling and chromatin conformation. The variety of epigenetic mechanisms allow high-end fine tuning and flexibility of gene expression, a prerequisite in the process of DC lineage development.
在这篇综述中，我们介绍了表观遗传基因调控的基本原理，并在树突状细胞（DC）发育和分化的背景下对其进行了讨论。表观遗传机制控制着染色质对 DNA 结合蛋白的可及性，从而控制基因表达。这些机制包括 DNA 和组蛋白的化学修饰、染色质重塑和染色质构象。多种表观遗传机制允许基因表达的精细调整和灵活性，这是 DC 谱系发育过程中的一个前提条件。
