Yang Ning, Zhang Pin-Liang, Liu Zeng-Jun
Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University.
Internal Medicine Department, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Medicine (Baltimore). 2020 Oct 30;99(44):e22933. doi: 10.1097/MD.0000000000022933.
Increasing evidence has shown that immune checkpoint inhibitors are associated with hyperprogressive disease (HPD). HPD usually resulted in dramatically reduced survival duration, which limited the opportunity to administer other therapies.
A heavily pretreated lung adenocarcinoma patient experienced rapid progression of rib metastasis soon after immune checkpoint inhibitor -based combination therapy.
On the basis of radiographic and pathological findings, the patient was diagnosed with HPD.
We treated the patient with iodine-125 radioactive particle implantation to the metastatic lesions in the chest wall.
The metastatic lesions shrank significantly 1 month later.
Early detection and adequate treatment are essential for prolonged survival when HPD occurs.
越来越多的证据表明，免疫检查点抑制剂与超进展性疾病（HPD）有关。HPD通常导致生存时间大幅缩短，这限制了给予其他治疗的机会。
一名经过大量治疗的肺腺癌患者在基于免疫检查点抑制剂的联合治疗后不久，肋骨转移迅速进展。
根据影像学和病理检查结果，该患者被诊断为HPD。
我们对患者胸壁的转移病灶进行了碘-125放射性粒子植入治疗。
1个月后转移病灶明显缩小。
HPD发生时，早期发现和充分治疗对于延长生存期至关重要。
