Antener I, Verwilghen A M, Van Geert C, Mauron J
Helv Paediatr Acta. 1978 Dec;33(6):543-62.
During the course of a malnutrition study, the efficiency of two diets has been followed by clinical observations and biochemical tests. The diets were adapted to the physiological state of 25 patients (16 children, 6 young mothers, 1 adolescent and 2 men) undergoing treatment in a rural hospital at Yasa-Bonga, Zaïre. One group of patients was examined after two weeks of treatment (6 children, 2 mothers), the other group after two months (8 children, 5 adults). In order to study the evolution of the illness, 9 children and 3 young mothers were examined regularly after the return to their villages every 6 months for 2-4 years. The patients responded positively to both diets. After two months of treatment they had clinically recovered, except for the most serious cases. After two weeks of treatment a deficiency in electrolytes, low levels of prealbumin and a net increase in transferrin were noted. After 2 months of treatment the children had regained their normal growth (hydroxyproline index), and most of the biochemical parameters had reached their normal value despite a few deficiencies in electrolytes, phosphorus and magnesium. However, the prealbumin level remained low, particularly amongst children suffering from relapses. In a few cases the activities of cholinesterase (CHE) and gamma-glutamyltranspeptidase (gamma-GT) remained low, which was taken as a sign of poor response to treatment. Generally, the adults responded more slowly to treatment than the children. Regular examinations carried out on certain patients on their return to the villages permitted 2 groups to be distinguished: the first one was composed of patients recuperating well due to good social conditions; the second group of patients suffered from relapses due to lack of hygiene and of rudimentary knowledge of nutrition, and above all severe social problems. The condition of the liver of all these patients was very important; it could be estimated by the determination of the serum levels of prealbumin and the activities of CHE, gamma-GT and isoenzymes of gamma-GT.
在一项营养不良研究过程中，通过临床观察和生化检测对两种饮食的效果进行了跟踪。这些饮食适合在扎伊尔亚萨 - 邦加的一家乡村医院接受治疗的25名患者（16名儿童、6名年轻母亲、1名青少年和2名男性）的生理状态。一组患者在治疗两周后接受检查（6名儿童、2名母亲），另一组在两个月后接受检查（8名儿童、5名成人）。为了研究病情的发展，9名儿童和3名年轻母亲在回到村庄后每6个月定期接受检查，持续2至4年。患者对两种饮食的反应均为积极。治疗两个月后，除了最严重的病例外，他们在临床上已康复。治疗两周后，发现存在电解质缺乏、前白蛋白水平低以及转铁蛋白净增加的情况。治疗两个月后，儿童恢复了正常生长（羟脯氨酸指数），尽管仍有一些电解质、磷和镁的缺乏，但大多数生化参数已达到正常水平。然而，前白蛋白水平仍然较低，尤其是在复发的儿童中。在少数情况下，胆碱酯酶（CHE）和γ-谷氨酰转肽酶（γ-GT）的活性仍然较低，这被视为对治疗反应不佳的迹象。一般来说，成年人对治疗的反应比儿童慢。对某些患者回到村庄后进行的定期检查使得可以区分出两组：第一组由因良好的社会条件而康复良好的患者组成；第二组患者由于缺乏卫生和基本的营养知识，尤其是严重的社会问题而复发。所有这些患者的肝脏状况非常重要；可以通过测定血清前白蛋白水平以及CHE、γ-GT和γ-GT同工酶的活性来评估。
