FIGO/ICM 指南：预防 Rh 同种免疫疾病——行动呼吁。
FIGO/ICM guidelines for preventing Rhesus disease: A call to action.
机构信息
International Federation of Gynecology and Obstetrics, London, UK.
Worldwide Initiative for Rh Disease Eradication, New York, NY, USA.
出版信息
Int J Gynaecol Obstet. 2021 Feb;152(2):144-147. doi: 10.1002/ijgo.13459. Epub 2021 Jan 9.
Abstract
The introduction of anti-Rh(D) immunoglobulin more than 50 years ago has resulted in only a 50% decrease in Rhesus disease globally owing to a low uptake of this prophylactic approach. The International Federation of Gynecology and Obstetrics, International Confederation of Midwives, and Worldwide Initiative for Rhesus Disease Eradication have reviewed current evidence regarding the utility of anti-Rh(D) immunoglobulin. Taking into account the effectiveness anti-Rh(D), the new guidelines propose adjusting the dose for different indications and prioritizing its administration by indication.
摘要
抗 Rh(D) 免疫球蛋白的引入已有 50 多年的历史，但由于这种预防方法的采用率较低，全球 Rh 溶血病的发病率仅降低了 50%。国际妇产科联合会、国际助产士联合会和全球消除 Rh 溶血病倡议组织审查了关于抗 Rh(D)免疫球蛋白效用的现有证据。考虑到抗 Rh(D) 的有效性，新指南建议根据不同的适应证调整剂量，并根据适应证优先给予。
相似文献
1
FIGO/ICM guidelines for preventing Rhesus disease: A call to action.FIGO/ICM 指南：预防 Rh 同种免疫疾病——行动呼吁。
Int J Gynaecol Obstet. 2021 Feb;152(2):144-147. doi: 10.1002/ijgo.13459. Epub 2021 Jan 9.
2
The use of anti-D immunoglobulins for rhesus prophylaxis: audit on knowledge and practices among obstetricians.抗 D 免疫球蛋白用于恒河猴预防：对产科医生知识和实践的审计。
Singapore Med J. 2009 Nov;50(11):1054-7.
3
[Text of the guidelines for prevention of fetomaternal rhesus-D allo-immunization].
J Gynecol Obstet Biol Reprod (Paris). 2006 Feb;35(1 Suppl):1S131-1S135.
4
Alloimmunization during pregnancy treated with high dose intravenous immunoglobulin. Effects on fetal hemoglobin concentration and anti-D concentrations in the mother and fetus.
Acta Obstet Gynecol Scand. 1995 Nov;74(10):777-83. doi: 10.3109/00016349509021196.
5
Rhesus immunization in pregnancy: a review.
Obstet Gynecol Surv. 1993 Dec;48(12):801-10. doi: 10.1097/00006254-199312000-00006.
6
RhD isoimmunization and current management modalities.RhD血型同种免疫及当前的管理模式。
J Obstet Gynecol Neonatal Nurs. 2001 Nov-Dec;30(6):589-606. doi: 10.1111/j.1552-6909.2001.tb00006.x.
7
8
Anti-D administration in pregnancy for preventing Rhesus alloimmunisation.孕期注射抗-D预防恒河猴血型同种免疫。
Cochrane Database Syst Rev. 2013 Feb 28(2):CD000020. doi: 10.1002/14651858.CD000020.pub2.
9
Occurrence of anti-D in RhD-positive mothers and the outcome of the newborns.
Acta Obstet Gynecol Scand. 1996 Jul;75(6):585-7. doi: 10.3109/00016349609054676.
10
Transfusion medicine illustrated. Miscounting even one lymphocyte in the Kleihauer-Betke (acid-elution) assay can result in overdosing Rh immune globulin.
Transfusion. 2015 Sep;55(9):2069. doi: 10.1111/trf.13056. Epub 2015 Feb 16.
引用本文的文献
1
Fetal treatment and long-term neonatal outcomes in severe maternal red cell alloimmunization - a single-centre experience.重度母婴红细胞同种免疫中的胎儿治疗及新生儿长期结局——单中心经验
Case Rep Perinat Med. 2025 Jun 9;14(1):20240040. doi: 10.1515/crpm-2024-0040. eCollection 2025 Jan.
2
Highlights from the International Twins Congress 2021.2021年国际双胞胎大会亮点。
Matern Fetal Med. 2022 Sep 11;4(4):293-296. doi: 10.1097/FM9.0000000000000166. eCollection 2022 Oct.
3
Point-of-care determination of the frequency of Rhesus(D)-negative blood types and the uptake of anti(D) immunoglobulin among Rh(D)-negative women in Dadu district, Sindh, Pakistan.巴基斯坦信德省达杜地区恒河猴（D）阴性血型频率的即时检测以及Rh（D）阴性女性中抗D免疫球蛋白的使用情况
PLOS Glob Public Health. 2025 Apr 9;5(4):e0004395. doi: 10.1371/journal.pgph.0004395. eCollection 2025.
4
Knowledge about Rh-incompatibility and its associated factors among antenatal care recipients in public hospitals of Wolaita zone, 2022: facility-based cross-sectional study.2022年沃莱塔地区公立医院产前护理接受者中Rh血型不相容性及其相关因素的知识：基于机构的横断面研究
BMJ Public Health. 2024 Apr 15;2(1):e000422. doi: 10.1136/bmjph-2023-000422. eCollection 2024 Jun.
5
General anaesthesia for nonobstetric surgery during pregnancy: A narrative review.孕期非产科手术的全身麻醉：一项叙述性综述。
Eur J Anaesthesiol Intensive Care. 2022 Aug 3;1(2):e003. doi: 10.1097/EA9.0000000000000003. eCollection 2022 Apr.
6
Hemolytic disease of the fetus and newborn and Rhesus alloimmunization in Latin American countries: a scoping review.拉丁美洲国家的胎儿和新生儿溶血病及恒河猴同种免疫：一项范围综述
BMC Pregnancy Childbirth. 2024 Dec 20;24(1):830. doi: 10.1186/s12884-024-07044-3.
7
Clinical Validation of a Prenatal Cell-Free DNA Screening Test for Fetal RHD in a Large U.S. Cohort.美国一个大型队列中胎儿RHD产前游离DNA筛查试验的临床验证
Obstet Gynecol. 2025 Feb 1;145(2):211-216. doi: 10.1097/AOG.0000000000005794. Epub 2024 Nov 26.
8
[Cell salvage in obstetrics-Background and practical implementation].[产科中的细胞回收——背景与实际应用]
Anaesthesiologie. 2024 Dec;73(12):843-851. doi: 10.1007/s00101-024-01479-1.
9
Immediate Care for Common Conditions in Term and Preterm Neonates: The Evidence.足月儿和早产儿常见病症的即时护理：证据
Neonatology. 2025;122(Suppl 1):106-128. doi: 10.1159/000541037. Epub 2024 Nov 12.
10
Colombian consensus for the diagnosis, prevention, and management of Rhesus disease.哥伦比亚共识：用于 Rh 血型不合疾病的诊断、预防和管理。
Rev Colomb Obstet Ginecol. 2024 Sep 30;75(3):4142. doi: 10.18597/rcog.4142.
本文引用的文献
1
Hemolytic disease of the fetus and newborn due to Rh(D) incompatibility: A preventable disease that still produces significant morbidity and mortality in children.由 Rh(D) 不相容引起的胎儿和新生儿溶血病：一种可预防的疾病，但仍会导致儿童出现严重的发病率和死亡率。
PLoS One. 2020 Jul 20;15(7):e0235807. doi: 10.1371/journal.pone.0235807. eCollection 2020.
2
Clinical value of different anti-D immunoglobulin strategies for preventing Rh hemolytic disease of the fetus and newborn: A network meta-analysis.不同抗 D 免疫球蛋白策略预防 Rh 溶血病胎儿和新生儿的临床价值：网状荟萃分析。
PLoS One. 2020 Mar 12;15(3):e0230073. doi: 10.1371/journal.pone.0230073. eCollection 2020.
3
Targeted antenatal anti-D prophylaxis for RhD-negative pregnant women: a systematic review.针对 RhD 阴性孕妇的靶向产前抗 D 预防：系统评价。
BMC Pregnancy Childbirth. 2020 Feb 7;20(1):83. doi: 10.1186/s12884-020-2742-4.
4
Anti-D prophylaxis for rhesus D (RhD)-negative women having an abortion of a pregnancy up to 13 weeks' gestation: a systematic review and new NICE consensus guidelines.对妊娠13周及以内流产的RhD阴性女性进行抗D预防：一项系统评价及英国国家卫生与临床优化研究所新的共识指南
BMJ Sex Reprod Health. 2020 Jan 20. doi: 10.1136/bmjsrh-2019-200536.
5
Single dose v two-dose antenatal anti-D prophylaxis: a randomised controlled trial.单剂与两剂产前抗 D 预防：一项随机对照试验。
Med J Aust. 2019 Sep;211(6):261-265. doi: 10.5694/mja2.50266. Epub 2019 Jul 14.
6
Do chorionic villus samplings (CVS) or amniocenteses (AC) induce RhD immunisation? An evaluation of a large Danish cohort with no routine administration of anti-D after invasive prenatal testing.绒毛膜绒毛取样 (CVS) 或羊膜穿刺术 (AC) 是否会引起 RhD 免疫？一项对丹麦大型队列的评估，该队列在侵入性产前检测后没有常规给予抗-D。
BJOG. 2019 Nov;126(12):1476-1480. doi: 10.1111/1471-0528.15861. Epub 2019 Jul 25.
7
The continuing burden of Rh disease 50 years after the introduction of anti-Rh(D) immunoglobin prophylaxis: call to action.抗 Rh(D)免疫球蛋白预防措施引入 50 年后 Rh 疾病持续存在的负担：行动呼吁。
Am J Obstet Gynecol. 2019 Sep;221(3):227.e1-227.e4. doi: 10.1016/j.ajog.2019.05.019. Epub 2019 May 20.
8
Practice Bulletin No. 181: Prevention of Rh D Alloimmunization.第181号实践公告：预防Rh D血型同种免疫
Obstet Gynecol. 2017 Aug;130(2):e57-e70. doi: 10.1097/AOG.0000000000002232.
9
Anti-D administration in pregnancy for preventing Rhesus alloimmunisation.孕期注射抗-D预防恒河猴血型同种免疫。
Cochrane Database Syst Rev. 2015 Sep 3;2015(9):CD000020. doi: 10.1002/14651858.CD000020.pub3.
10
Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels.新生儿高胆红素血症和新生儿 Rh 溶血病：2010 年按区域和全球水平估计的发病率和损害程度。
Pediatr Res. 2013 Dec;74 Suppl 1(Suppl 1):86-100. doi: 10.1038/pr.2013.208.
Zotero 插件