Verma R S, Macera M J
Division of Genetics, Long Island College Hospital, Brooklyn, NY 11201.
Leuk Res. 1987;11(9):833-42. doi: 10.1016/0145-2126(87)90068-3.
The incidence of breakpoints in CML patients with variant translocations was investigated. There was no relationship between the length of various chromosomes with breakpoint frequency. However, a significantly higher (p less than 0.05) incidence of breaks were seen on the long arms as compared to the short arms due mainly to the involvement of 9q and 22q in these translocations. Chromosome 17 showed a significantly (p less than 0.005) higher involvement in these translocations, however only when 9q34-qter was not cytogenetically involved. A total of 683 breaks were found in 225 cases. 362 of these were located at c-abl and c-sis, while 110 were at other oncogenetic sites. The prognostic and hematologic features of patients with variant translocations are not significantly different from those of CML cases with the typical 9q;22q translocation. Some of these complex translocation, where the breakpoints are correlated with oncogenetic sites, are further discussed in molecular terms.
对具有变异易位的慢性粒细胞白血病（CML）患者的断点发生率进行了研究。各种染色体的长度与断点频率之间没有关系。然而，与短臂相比，长臂上的断点发生率显著更高（p<0.05），这主要是由于这些易位中9号染色体长臂（9q）和22号染色体长臂（22q）的参与。17号染色体在这些易位中的参与率显著更高（p<0.005），但仅在细胞遗传学上9q34-qter未受累时如此。在225例病例中总共发现了683个断点。其中362个位于c-abl和c-sis，而110个位于其他致癌基因位点。具有变异易位的患者的预后和血液学特征与具有典型9q;22q易位的CML病例没有显著差异。其中一些复杂易位，其断点与致癌基因位点相关，将在分子层面进一步讨论。
