Department of Periodontology, Nihon University School of Dentistry at Matsudo, Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan.
Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan.
J Periodontol. 2021 Jul;92(7):983-994. doi: 10.1002/JPER.20-0481. Epub 2020 Nov 20.
Human fibroblast growth factor-2 (rhFGF-2) therapy has been used for periodontal tissue regeneration. However, few studies have reported their adjunctive procedures based on strategy of tissue engineering. The aim of this retrospective study is to assess the adjunctive effects of modified papilla preservation technique (mPPT) and combination with autogenous bone grafts (AG) on the rhFGF-2 therapy.
Total of 44 sites underwent rhFGF-2 therapies and the evaluations in the survey periods. The primary outcome was set to the radiographic bone fill by radiographic examinations at 6 and 12 months after surgeries. We analyzed the correlation between influencing factors and the primary outcome, and differences of therapeutic effect by combination therapy with mPPT and that with AG.
After surgeries, probing depth (PD), clinical attachment level (CAL) and bone defects significantly improved. The improvements of radiographic bone fill were significantly positive correlated with a number of bone walls, combination with mPPT, and AG at 6 months after surgeries, and with combination with mPPT and AG at 12 months after surgeries. The significant differences of improvements of radiographic bone fill were demonstrated between combination with or without mPPT at 12 months after surgeries, and with or without AG at 6 and 12 months after surgeries. Moreover, the multiple linear regression analysis for the radiographic bone fill indicated the significant regression coefficient with conducts of mPPT.
mPPT and AG had powerfully adjunctive effects on rhFGF-2 therapy. Further studies are needed in order to verify by randomized clinical trials.
人成纤维细胞生长因子-2（rhFGF-2）治疗已被用于牙周组织再生。然而，很少有研究报道基于组织工程策略的辅助程序。本回顾性研究的目的是评估改良乳头保留技术（mPPT）和联合自体骨移植（AG）对 rhFGF-2 治疗的辅助作用。
共有 44 个部位接受了 rhFGF-2 治疗，并在调查期间进行了评估。主要结果是通过术后 6 个月和 12 个月的放射检查评估放射状骨填充。我们分析了影响因素与主要结果之间的相关性，以及 mPPT 联合治疗和 AG 联合治疗的疗效差异。
手术后，探诊深度（PD）、临床附着水平（CAL）和骨缺损均明显改善。术后 6 个月，放射状骨填充的改善与骨壁数量、mPPT 联合治疗和 AG 呈显著正相关，术后 12 个月与 mPPT 联合治疗和 AG 呈显著正相关。术后 12 个月，mPPT 联合治疗与非 mPPT 联合治疗之间，以及术后 6 个月和 12 个月，AG 联合治疗与非 AG 联合治疗之间，放射状骨填充的改善差异有统计学意义。此外，放射状骨填充的多元线性回归分析表明，mPPT 的作用具有显著的回归系数。
mPPT 和 AG 对 rhFGF-2 治疗具有强大的辅助作用。需要进一步的随机临床试验来验证。
