Torras H, Bombi J A
Departamento de Dermatología, Hospital Clínico y Facultad de Medicina de Barcelona.
Med Cutan Ibero Lat Am. 1987;15(3):179-84.
The authors studied PUVA induced ultrastructural alterations in a group of 7 patients compared with 6 control subjects of same age. Hyperactivity of melanocytes was observed in all patients. Elastic fibers showed vacuolisation age and dose related. There was a reduplication of the basal layer of dermal capillaries and increased pinocytosis of endothelial cells, age and dose related also. The authors conclude that PUVA therapy induced alterations are degenerative; the target is located in deep dermis (capillaries and elastic fibers). No alterations of keratinocytes nor precancerous epithelial dysplasia was found. This confirms that UVA radiation is less aggressive for keratinocytes than UVB.
作者对7名患者与6名同龄对照受试者进行了研究，观察补骨脂素加紫外线A（PUVA）诱导的超微结构改变。在所有患者中均观察到黑素细胞活性增强。弹性纤维出现空泡化，与年龄和剂量相关。真皮毛细血管基底层重复，内皮细胞胞饮作用增强，也与年龄和剂量相关。作者得出结论，PUVA治疗引起的改变是退行性的；靶点位于真皮深层（毛细血管和弹性纤维）。未发现角质形成细胞改变或癌前上皮发育异常。这证实了紫外线A（UVA）辐射对角质形成细胞的侵袭性低于紫外线B（UVB）。
