Piérard-Franchimont C, Nickels-Read D, Ben Mosbah T, Arrese Estrada J, Piérard G E
Department of Dermatopathology, University of Liège, Belgium.
J Pathol. 1990 Jul;161(3):227-31. doi: 10.1002/path.1711610309.
The combination of trioxsalen bath and long-wave UV-A is used in dermatology to treat selected patients with psoriasis. Such treatment induces side effects whose clinical aspects have already been described. We report the histological aspects of these lesions. The most striking features occur in the epidermis, where we found vacuolar alterations, disorganization of the stratum malpighi, necrotic cells, and Bowenoid changes. Langerhans cells are reduced in number, and melanocytes may become large and atypical. In addition, factor XIIIa-positive dendrocytes of the superficial dermis increase in size, and some of them migrate into the epidermis, which is a rare location for these cells.
三甲沙林浴和长波紫外线A联合使用在皮肤科用于治疗特定的银屑病患者。这种治疗会引发一些副作用，其临床症状已经有过描述。我们报告这些病变的组织学特征。最显著的特征出现在表皮，我们发现有空泡样改变、马尔皮基层紊乱、坏死细胞以及鲍温样改变。朗格汉斯细胞数量减少，黑素细胞可能会变大且呈非典型性。此外，浅表真皮中因子ⅩⅢa阳性的树突状细胞体积增大，其中一些迁移至表皮，而这对这些细胞来说是一个罕见的位置。
