一种用于设计硫醇触发型传感器和前药的模块化模板。
A modular template for the design of thiol-triggered sensors and prodrugs.
机构信息
Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
Department of Chemistry, Brown University, Providence, RI 02912, USA.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Feb 15;247:119072. doi: 10.1016/j.saa.2020.119072. Epub 2020 Oct 13.
Abstract
A unique reaction between thiols (RSH) and alkyl sulfonylbenzothiazole was discovered. This reaction was specific for thiols and produced a sulfinic acid (RSOH) as the intermediate, which further triggered an intramolecular cyclization to release a -OH containing payload. This reaction was used to develop thiol-triggered fluorescent sensors and prodrugs. The modular design of this template provides tunability of the release profiles of the payloads.
摘要
研究发现了巯基（RSH）和烷基磺酰基苯并噻唑之间的独特反应。该反应特异性针对巯基，并产生亚磺酸（RSOH）作为中间体，进一步引发分子内环化，释放含有-OH 的有效载荷。该反应被用于开发巯基触发的荧光传感器和前药。该模板的模块化设计提供了有效载荷释放谱的可调节性。
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