Wu Yuxuan, Wang Jihui, Li Lin, Fei Xu, Xu Longquan, Wang Yi, Tian Jing, Li Yao
Instrumental Analysis Center, Dalian Polytechnic University, Dalian 116034, China; School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China.
School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China; School of Chemical Engineering & Energy Technology, Dongguan University of Technology, Dongguan 528808, China.
J Colloid Interface Sci. 2021 Feb 15;584:484-494. doi: 10.1016/j.jcis.2020.09.105. Epub 2020 Oct 12.
In this study, we have designed and synthesized a novel poly (4 - vinyl benzene boronic acid - co - N - vinyl pyrrolidone - co - 1 - vinyl - 3 - butylimidazolium bromide) hydrogel (VNV hydrogel) dressing with good self-healing properties and bactericidal activity. The gelation and self-healing of this hydrogel are mainly achieved by the formation of a dynamic B-O-B bond between the polymer chains, which is fractured by external forces and subsequently reformed. This self-healing mechanism is studied in detail through the molecular design of the hydrogel. The introduction of hydrophilic chemical groups can effectively improve the porous structures, water absorption and molecular migration. These properties have a positive effect on improving self-healing properties of dynamic crosslinked hydrogels. Furthermore, this VNV hydrogel dressing displays good antibacterial activity against E. coli, S. aureus, and C. albicans. The application of VNV hydrogel dressing on rat wound surface can effectively accelerate wound healing. These results indicate that this novel VNV hydrogel dressing with good self-healing properties and bactericidal activity has potential applications in wound dressings.
在本研究中，我们设计并合成了一种新型的聚（4-乙烯基苯硼酸-co-N-乙烯基吡咯烷酮-co-1-乙烯基-3-丁基咪唑溴盐）水凝胶（VNV水凝胶）敷料，其具有良好的自愈性能和杀菌活性。这种水凝胶的凝胶化和自愈主要通过聚合物链之间形成动态的B-O-B键来实现，该键会因外力而断裂，随后重新形成。通过水凝胶的分子设计对这种自愈机制进行了详细研究。亲水性化学基团的引入可以有效改善多孔结构、吸水性和分子迁移。这些特性对改善动态交联水凝胶的自愈性能有积极作用。此外，这种VNV水凝胶敷料对大肠杆菌、金黄色葡萄球菌和白色念珠菌显示出良好的抗菌活性。将VNV水凝胶敷料应用于大鼠伤口表面可有效加速伤口愈合。这些结果表明，这种具有良好自愈性能和杀菌活性的新型VNV水凝胶敷料在伤口敷料方面具有潜在应用价值。
