Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Small. 2022 Jun;18(25):e2201620. doi: 10.1002/smll.202201620. Epub 2022 May 22.
It is challenging for traditional wound dressings to adapt to the complex and changeable environment, due to the lack of stable, efficient, and continuous bactericidal activity. They also cannot be satisfied in a multifunctional sensing platform to reconstruct skin sensory functions for human health monitoring. A multifunctional hydrogel dressing is developed here for the treatment of infected wounds and human health monitoring, which is based on alginate and polycation. The in situ polymerization and solvent displacement method are used to functionalize the hydrogel for the improvement of antifreezing, water retention, and environmental adaptability, as well as the adhesion and photothermal property. As a wound dressing, the as-prepared hydrogel exhibits an excellent antibacterial property against both Escherichia coli and Staphylococcus aureus. In a rat model of full-thickness wound infection, it significantly accelerates the healing of infected wounds with a high healing rate of 96.49%. In the further multifunctional sensory tests, the hydrogel shows multiple response modes of strain, pressure and temperature, and sensing stability. An idea is provided here to develop a smart hydrogel dressing that can accelerate wound healing and achieve human health monitoring.
传统的伤口敷料由于缺乏稳定、高效和持续的杀菌活性，难以适应复杂多变的环境。它们也无法在多功能传感平台上满足需求，无法重建皮肤的感觉功能，以实现人类健康监测。本文开发了一种基于海藻酸盐和聚阳离子的多功能水凝胶敷料，用于治疗感染性伤口和人类健康监测。该水凝胶采用原位聚合和溶剂置换法进行功能化，以提高其抗冻性、保水性和环境适应性，以及粘附性和光热性能。作为一种伤口敷料，所制备的水凝胶对大肠杆菌和金黄色葡萄球菌均表现出优异的抗菌性能。在全层伤口感染的大鼠模型中，它能显著加速感染伤口的愈合，愈合率高达 96.49%。在进一步的多功能传感测试中，水凝胶显示出多种应变、压力和温度的响应模式以及传感稳定性。本文为开发一种可加速伤口愈合和实现人类健康监测的智能水凝胶敷料提供了一种思路。
