慢性肾脏病相关的大脑结构和功能变化综述。
Review of the structural and functional brain changes associated with chronic kidney disease.
机构信息
Department of Radiology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic.
出版信息
Physiol Res. 2020 Dec 22;69(6):1013-1028. doi: 10.33549/physiolres.934420. Epub 2020 Nov 2.
Abstract
Chronic kidney disease (CKD) leads to profound metabolic and hemodynamic changes, which damage other organs, such as heart and brain. The brain abnormalities and cognitive deficit progress with the severity of the CKD and are mostly expressed among hemodialysis patients. They have great socio-economic impact. In this review, we present the current knowledge of involved mechanisms.
摘要
慢性肾脏病（CKD）导致深刻的新陈代谢和血液动力学的变化，从而损害其他器官，如心脏和大脑。大脑异常和认知缺陷随着 CKD 的严重程度而进展，并且大多出现在血液透析患者中。它们具有重大的社会经济影响。在这篇综述中，我们介绍了相关机制的现有知识。
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