• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

DNA复制方向对N-甲基-N'-硝基-N-亚硝基胍在大肠杆菌适应细胞中诱变作用的影响。

Effect of the direction of DNA replication on mutagenesis by N-methyl-N'-nitro-N-nitrosoguanidine in adapted cells of Escherichia coli.

作者信息

Reed J, Hutchinson F

机构信息

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511.

出版信息

Mol Gen Genet. 1987 Jul;208(3):446-9. doi: 10.1007/BF00328137.

DOI:10.1007/BF00328137
PMID:3312948
Abstract

The methylating agent N-methyl-N'-nitro-N-nitrosoguanidine preferentially induces G:C to A:T transitions at DNA base pairs with the G in one particular strand of the cI gene in a lambda prophage, in this case the nontranscribed strand, in Escherichia coli cells in which the adaptive response is induced. The same preference is found for the cI gene inserted in the genome in the inverse orientation, so the differential effect is not caused by the direction of motion of the DNA replicating fork.

摘要

甲基化剂N-甲基-N'-硝基-N-亚硝基胍在诱导了适应性反应的大肠杆菌细胞中，优先在λ原噬菌体cI基因的一条特定链（在这种情况下为非转录链）上具有G的DNA碱基对处诱导G:C到A:T的转换。对于以相反方向插入基因组的cI基因也发现了相同的偏好，因此这种差异效应不是由DNA复制叉的移动方向引起的。

相似文献

1
Effect of the direction of DNA replication on mutagenesis by N-methyl-N'-nitro-N-nitrosoguanidine in adapted cells of Escherichia coli.DNA复制方向对N-甲基-N'-硝基-N-亚硝基胍在大肠杆菌适应细胞中诱变作用的影响。
Mol Gen Genet. 1987 Jul;208(3):446-9. doi: 10.1007/BF00328137.
2
The complexity of nitrosoguanidine mutagenesis increases with size: observations of the mutational specificity of N-propyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis. 1989 May;10(5):949-52. doi: 10.1093/carcin/10.5.949.
3
Influence of neighbouring base sequence on N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis in the lacI gene of Escherichia coli.相邻碱基序列对大肠杆菌lacI基因中N-甲基-N'-硝基-N-亚硝基胍诱变的影响。
J Mol Biol. 1987 Apr 5;194(3):385-90. doi: 10.1016/0022-2836(87)90668-1.
4
DNA base changes induced following in vivo exposure of unadapted, adapted or ada- Escherichia coli to N-methyl-N'-nitro-N-nitrosoguanidine.未适应、适应或ada - 大肠杆菌在体内暴露于N - 甲基 - N'- 硝基 - N - 亚硝基胍后诱导的DNA碱基变化。
Mol Gen Genet. 1987 Oct;209(3):526-32. doi: 10.1007/BF00331159.
5
Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the tonB gene on the chromosome of Escherichia coli recA+ and recA- cells.N-甲基-N'-硝基-N-亚硝基胍对大肠杆菌recA+和recA-细胞染色体上tonB基因的诱变特异性。
Biochem Biophys Res Commun. 1996 Oct 14;227(2):334-9. doi: 10.1006/bbrc.1996.1510.
6
Mutation spectra of N-ethyl-N'-nitro-N-nitrosoguanidine and 1-(2-hydroxyethyl)-1-nitrosourea in Escherichia coli.大肠杆菌中N-乙基-N'-硝基-N-亚硝基胍和1-(2-羟乙基)-1-亚硝基脲的突变谱
Mol Gen Genet. 1988 Nov;214(3):460-6. doi: 10.1007/BF00330481.
7
N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation in a RecA strain of Escherichia coli.
Mutat Res. 1988 Sep;201(1):219-28. doi: 10.1016/0027-5107(88)90129-7.
8
Comparative mutagenesis of O6-methylguanine and O4-methylthymine in Escherichia coli.
Biochemistry. 1991 Jul 16;30(28):7027-33. doi: 10.1021/bi00242a031.
9
N-methyl-N'-nitro-N-nitrosoguanidine induced DNA sequence alteration; non-random components in alkylation mutagenesis.
Mutat Res. 1990 Nov-Dec;233(1-2):95-103. doi: 10.1016/0027-5107(90)90154-v.
10
Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the gpt gene on a chromosome of Chinese hamster ovary cells and of Escherichia coli cells.N-甲基-N'-硝基-N-亚硝基胍对中国仓鼠卵巢细胞和大肠杆菌细胞染色体上gpt基因的诱变特异性。
Mol Gen Genet. 1991 Jun;227(2):252-9. doi: 10.1007/BF00259678.

引用本文的文献

1
Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.MSH2基因缺陷小鼠的组织在暴露于DNA甲基化剂时表现出高突变性。
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1126-30. doi: 10.1073/pnas.95.3.1126.
2
Mechanisms of transcription-repair coupling and mutation frequency decline.转录修复偶联机制与突变频率下降
Microbiol Rev. 1994 Sep;58(3):317-29. doi: 10.1128/mr.58.3.317-329.1994.
3
DNA base changes induced following in vivo exposure of unadapted, adapted or ada- Escherichia coli to N-methyl-N'-nitro-N-nitrosoguanidine.

本文引用的文献

1
Quantitation of the adaptive response to alkylating agents.烷化剂适应性反应的定量分析。
Nature. 1979 Jul 5;280(5717):74-6. doi: 10.1038/280074a0.
2
Mismatch correction at O6-methylguanine residues in E. coli DNA.大肠杆菌DNA中O6-甲基鸟嘌呤残基的错配修复
Nature. 1982 Apr 29;296(5860):868-9. doi: 10.1038/296868a0.
3
Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents.诱导一种针对N-甲基化嘌呤的DNA糖基化酶是对烷化剂适应性反应的一部分。
未适应、适应或ada - 大肠杆菌在体内暴露于N - 甲基 - N'- 硝基 - N - 亚硝基胍后诱导的DNA碱基变化。
Mol Gen Genet. 1987 Oct;209(3):526-32. doi: 10.1007/BF00331159.
4
Mutation spectra of N-ethyl-N'-nitro-N-nitrosoguanidine and 1-(2-hydroxyethyl)-1-nitrosourea in Escherichia coli.大肠杆菌中N-乙基-N'-硝基-N-亚硝基胍和1-(2-羟乙基)-1-亚硝基脲的突变谱
Mol Gen Genet. 1988 Nov;214(3):460-6. doi: 10.1007/BF00330481.
5
Sequence specificity of streptozotocin-induced mutations.链脲佐菌素诱导突变的序列特异性。
Nucleic Acids Res. 1988 Oct 25;16(20):9811-20. doi: 10.1093/nar/16.20.9811.
6
Inosine induced mutations.肌苷诱导的突变。
Mol Gen Genet. 1988 Sep;214(1):62-7. doi: 10.1007/BF00340180.
7
Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the gpt gene on a chromosome of Chinese hamster ovary cells and of Escherichia coli cells.N-甲基-N'-硝基-N-亚硝基胍对中国仓鼠卵巢细胞和大肠杆菌细胞染色体上gpt基因的诱变特异性。
Mol Gen Genet. 1991 Jun;227(2):252-9. doi: 10.1007/BF00259678.
8
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.哺乳动物细胞对烷基化损伤的抗性中的自我破坏与耐受性
Nucleic Acids Res. 1992 Jun 25;20(12):2933-40. doi: 10.1093/nar/20.12.2933.
Nature. 1982 Apr 22;296(5859):770-3. doi: 10.1038/296770a0.
4
Role of the uvrE gene product and of inducible O6-methylguanine removal in the induction of mutations by N-methyl-N'-nitro-N-nitrosoguanidine in Escherichia coli.uvrE基因产物及诱导性O6-甲基鸟嘌呤去除在大肠杆菌中N-甲基-N'-硝基-N-亚硝基胍诱导突变中的作用。
J Mol Biol. 1980 Nov 15;143(4):343-62. doi: 10.1016/0022-2836(80)90217-x.
5
Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.大肠杆菌中烷基化DNA的修复。甲基从O6-甲基鸟嘌呤转移至蛋白质半胱氨酸残基。
J Biol Chem. 1980 Nov 25;255(22):10569-71.
6
The incorporation of O6-methyldeoxyguanosine and O4-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and alpha.DNA聚合酶I和α将O6-甲基脱氧鸟苷单磷酸和O4-甲基脱氧胸苷单磷酸掺入DNA中。
Nucleic Acids Res. 1983 Jun 25;11(12):4185-93. doi: 10.1093/nar/11.12.4185.
7
Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.大肠杆菌O6-甲基鸟嘌呤-DNA甲基转移酶的自杀性失活
EMBO J. 1982;1(11):1359-63. doi: 10.1002/j.1460-2075.1982.tb01323.x.
8
O6-methylguanine methyltransferase in rat liver.
Biochemistry. 1983 Aug 2;22(16):3759-63. doi: 10.1021/bi00285a007.
9
Repair of DNA base-pair mismatches in extracts of Escherichia coli.大肠杆菌提取物中DNA碱基对错配的修复
Cold Spring Harb Symp Quant Biol. 1984;49:589-96. doi: 10.1101/sqb.1984.049.01.066.
10
Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.大肠杆菌中O-烷基化DNA嘧啶的诱导修复
EMBO J. 1984 Mar;3(3):545-50. doi: 10.1002/j.1460-2075.1984.tb01844.x.