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1
The incorporation of O6-methyldeoxyguanosine and O4-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and alpha.DNA聚合酶I和α将O6-甲基脱氧鸟苷单磷酸和O4-甲基脱氧胸苷单磷酸掺入DNA中。
Nucleic Acids Res. 1983 Jun 25;11(12):4185-93. doi: 10.1093/nar/11.12.4185.
2
The incorporation of O6-methyldeoxyguanosine monophosphate and O4-methyldeoxythymidine monophosphate into polynucleotide templates leads to errors during subsequent in vitro DNA synthesis.将O6-甲基脱氧鸟苷单磷酸和O4-甲基脱氧胸苷单磷酸掺入多核苷酸模板会在随后的体外DNA合成过程中导致错误。
Chem Biol Interact. 1985 Dec 31;56(2-3):363-70. doi: 10.1016/0009-2797(85)90017-1.
3
Kinetics of incorporation of O6-methyldeoxyguanosine monophosphate during in vitro DNA synthesis.体外DNA合成过程中O6-甲基脱氧鸟苷单磷酸掺入的动力学
Biochemistry. 1984 Sep 11;23(19):4289-94. doi: 10.1021/bi00314a006.
4
Effect of sequence contexts on misincorporation of nucleotides opposite 2-hydroxyadenine.序列上下文对与2-羟基腺嘌呤相对的核苷酸错掺入的影响。
FEBS Lett. 1996 Aug 5;391(1-2):113-6. doi: 10.1016/0014-5793(96)00714-4.
5
Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase.人DNA聚合酶α、聚合酶γ和引发酶对2'-氟-dNTP和2'-O-甲基-dNTP的聚合作用。
Biochem Pharmacol. 2000 May 1;59(9):1045-52. doi: 10.1016/s0006-2952(99)00414-1.
6
The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect ones.酿酒酵母DNA聚合酶α的甘氨酸-952残基在区分正确与错误的脱氧核糖核苷酸方面很重要。
J Biol Chem. 2003 May 23;278(21):19079-86. doi: 10.1074/jbc.M208604200. Epub 2003 Mar 7.
7
Base-pairing properties of O6-methylguanine in template DNA during in vitro DNA replication.体外DNA复制过程中模板DNA中O6-甲基鸟嘌呤的碱基配对特性。
J Biol Chem. 1984 Jul 10;259(13):8095-100.
8
Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases.8-氧代-7,8-二氢鸟苷三磷酸掺入及复制性和修复性DNA聚合酶延伸的稳态和预稳态动力学分析。
Biochemistry. 1998 Sep 22;37(38):13300-12. doi: 10.1021/bi981346d.
9
Klenow fragment-DNA interaction required for the incorporation of nucleotides opposite guanine and O6-methylguanine.掺入与鸟嘌呤和O6-甲基鸟嘌呤相对的核苷酸所需的Klenow片段与DNA的相互作用。
Biochemistry. 1997 Oct 28;36(43):13292-7. doi: 10.1021/bi971253g.
10
Escherichia coli polymerase I can use O2-methyldeoxythymidine or O4-methyldeoxythymidine in place of deoxythymidine in primed poly(dA-dT).poly(dA-dT) synthesis.在引发的聚（dA-dT）·聚（dA-dT）合成中，大肠杆菌聚合酶I可以使用O2-甲基脱氧胸苷或O4-甲基脱氧胸苷来替代脱氧胸苷。
Proc Natl Acad Sci U S A. 1983 Aug;80(16):4884-8. doi: 10.1073/pnas.80.16.4884.

引用本文的文献

1
A non-surgical method for induction of lung cancer in Wistar rats using a combination of NNK and high dietary fats.采用 NNK 和高脂肪饮食相结合的非手术方法诱导 Wistar 大鼠肺癌。
Protoplasma. 2013 Aug;250(4):919-29. doi: 10.1007/s00709-012-0478-3. Epub 2013 Jan 13.
2
Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.大肠杆菌中O-烷基化DNA嘧啶的诱导修复
EMBO J. 1984 Mar;3(3):545-50. doi: 10.1002/j.1460-2075.1984.tb01844.x.
3
Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.对抗烷基化诱变的自杀性甲基转移酶的活性位点及完整序列。
Proc Natl Acad Sci U S A. 1985 May;82(9):2688-92. doi: 10.1073/pnas.82.9.2688.
4
Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair.通过颠覆性修复可能耗尽人类淋巴瘤细胞中的一种DNA修复酶。
Proc Natl Acad Sci U S A. 1985 Aug;82(16):5285-9. doi: 10.1073/pnas.82.16.5285.
5
DNA sequence analysis of mutagenicity and site specificity of ethyl methanesulfonate in Uvr+ and UvrB- strains of Escherichia coli.甲磺酸乙酯在大肠杆菌Uvr⁺和UvrB⁻菌株中的诱变性和位点特异性的DNA序列分析
Genetics. 1986 Aug;113(4):811-9. doi: 10.1093/genetics/113.4.811.
6
Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis.通过酶促位点特异性诱变方法测定体内O4-甲基胸腺嘧啶的诱变潜力。
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8501-5. doi: 10.1073/pnas.83.22.8501.
7
O4-Methyl, -ethyl, or -isopropyl substituents on thymidine in poly(dA-dT) all lead to transitions upon replication.聚（dA-dT）中胸苷上的O4-甲基、-乙基或-异丙基取代基在复制时都会导致转变。
Proc Natl Acad Sci U S A. 1986 Jan;83(1):28-32. doi: 10.1073/pnas.83.1.28.
8
Induction of mutation in mouse FM3A cells by N4-aminocytidine-mediated replicational errors.N4-氨基胞苷介导的复制错误在小鼠FM3A细胞中诱导突变
Mol Cell Biol. 1988 Jan;8(1):347-52. doi: 10.1128/mcb.8.1.347-352.1988.
9
Effect of the direction of DNA replication on mutagenesis by N-methyl-N'-nitro-N-nitrosoguanidine in adapted cells of Escherichia coli.DNA复制方向对N-甲基-N'-硝基-N-亚硝基胍在大肠杆菌适应细胞中诱变作用的影响。
Mol Gen Genet. 1987 Jul;208(3):446-9. doi: 10.1007/BF00328137.

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Incorporation of 6-thioguanine into nucleic acids.6-硫鸟嘌呤掺入核酸。
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CONVERSION OF MONO- AND OLIGODEOXYRIBONUCLEOTIDES TO 5-TRIPHOSPHATES.单脱氧核糖核苷酸和寡脱氧核糖核苷酸向5-三磷酸酯的转化。
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The effects of methylated thymidines upon cultures of V79 cells and the mechanism of incorporation of O4-methylthymidine into their DNA.甲基化胸苷对V79细胞培养物的影响以及O4-甲基胸苷掺入其DNA的机制。
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Synthesis of 8-14C-labeled O6-methyldeoxyguanosine and its deoxynucleotide copolymers.8-¹⁴C标记的O⁶-甲基脱氧鸟苷及其脱氧核苷酸共聚物的合成。
Biochemistry. 1980 Feb 19;19(4):643-7. doi: 10.1021/bi00545a006.
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Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides.脱氧鸟苷的O-6烷基化与亚硝胺和亚硝酰胺的致突变性和致癌性之间可能存在的关联。
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9
Synthesis and chemical properties of monomers and polymers containing 7-methylguanine and an investigation of their substrate or template properties for bacterial deoxyribonucleic acid or ribonucleic acid polymerases.含7-甲基鸟嘌呤的单体和聚合物的合成及化学性质，以及它们作为细菌脱氧核糖核酸或核糖核酸聚合酶的底物或模板性质的研究。
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10
Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O4-methylthymidine.N-甲基-N-亚硝基脲与含胸苷残基的脱氧核糖核酸的反应产物。一种新的甲基化产物O4-甲基胸苷的合成与鉴定。
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DNA聚合酶I和α将O6-甲基脱氧鸟苷单磷酸和O4-甲基脱氧胸苷单磷酸掺入DNA中。

The incorporation of O6-methyldeoxyguanosine and O4-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and alpha.

作者信息

Hall J A, Saffhill R

出版信息

Nucleic Acids Res. 1983 Jun 25;11(12):4185-93. doi: 10.1093/nar/11.12.4185.

DOI:10.1093/nar/11.12.4185
PMID:6866769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC326033/
Abstract

The modified nucleoside 5'-triphosphates O6-MedGTP ad O4-MedTTP have been synthesised and their acceptability as DNA-precursors investigated using DNA polymerases I and alpha in an in vitro assay. O6-MedGMP is only incorporated into newly-synthesized DNA-like material in the presence of templates containing thymine bases. Similarly O4-MedTMP is only incorporated in the presence of templates containing guanine bases. The results confirm the promutagenic nature and base-pairing properties of O6-MeG ad O4-MeT.

摘要

已合成了修饰核苷5'-三磷酸O6-甲基鸟苷三磷酸（O6-MedGTP）和O4-甲基胸苷三磷酸（O4-MedTTP），并在体外试验中使用DNA聚合酶I和α研究了它们作为DNA前体的可接受性。只有在含有胸腺嘧啶碱基的模板存在下，O6-甲基鸟苷一磷酸（O6-MedGMP）才会掺入新合成的类DNA物质中。同样，只有在含有鸟嘌呤碱基的模板存在下，O4-甲基胸苷一磷酸（O4-MedTMP）才会掺入。结果证实了O6-甲基鸟嘌呤（O6-MeG）和O4-甲基胸腺嘧啶（O4-MeT）的促诱变性质和碱基配对特性。