pHLA3D：更新 HLA-DR、HLA-DQ 和 HLA-DP 分子的 HLA 三维结构预测数据库。
pHLA3D: Updating the database of predicted three-dimensional structures of HLA with HLA-DR, HLA-DQ and HLA-DP molecules.
机构信息
Laboratory of Immunogenetics and Molecular Biology, Federal University of Piauí, Teresina, PI, Brazil.
Laboratory of Immunogenetics and Molecular Biology, Federal University of Piauí, Teresina, PI, Brazil; Department of Computation, Federal University of Piauí, Teresina, PI, Brazil.
出版信息
Hum Immunol. 2021 Jan;82(1):8-10. doi: 10.1016/j.humimm.2020.10.007. Epub 2020 Oct 28.
To improve the availability of three-dimensional (3D) structures of HLA molecules, we created the pHLA3D database. In its first version, we modeled and published 106 3D structures of HLA class I molecules from the HLA-A, HLA-B, and HLA-C loci. This paper presents an update of this database, providing more 127 3D structures of HLA class II molecules (41 DR, 42 DQ, and 44 DP), predicted via homology modeling with MODELLER and SWISS-MODEL. These new 3D structures of HLA class II molecules are now freely available at pHLA3D (www.phla3d.com.br) for immunologists and other researchers working with HLA molecules.
为了提高人类白细胞抗原（HLA）分子三维（3D）结构的可用性，我们创建了 pHLA3D 数据库。在其第一个版本中，我们通过同源建模和 MODELLER 以及 SWISS-MODEL 预测，对来自 HLA-A、HLA-B 和 HLA-C 基因座的 106 个 HLA 类 I 分子的 3D 结构进行了建模和发表。本文介绍了该数据库的更新，提供了更多 HLA 类 II 分子（41DR、42DQ 和 44DP）的 127 个 3D 结构，这些结构是通过同源建模和 MODELLER 以及 SWISS-MODEL 预测得到的。这些 HLA 类 II 分子的新 3D 结构现在可以在 pHLA3D（www.phla3d.com.br）上免费获得，供免疫学家和其他研究 HLA 分子的研究人员使用。
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