Associate Director, Adult Transfusion Medicine, Brigham and Women's Hospital, Boston, MA.
Director, Blood Transfusion Service, Massachusetts General Hospital, Boston, MA.
Transfus Med Rev. 2020 Oct;34(4):242-249. doi: 10.1016/j.tmrv.2020.09.002. Epub 2020 Sep 17.
Refractoriness to platelet transfusion is a common clinical problem encountered by the transfusion medicine specialist. It is well recognized that most causes of refractoriness to platelet transfusion are not a consequence of alloimmunization to human leukocyte, platelet-specific, or ABO antigens, but are a consequence of platelet sequestration and consumption. This review summarizes the clinical factors that result in platelet refractoriness and highlights recent data describing novel biological mechanisms that contribute to this clinical problem.
血小板输注无效是输血医学专家经常遇到的一个临床问题。人们普遍认识到，大多数血小板输注无效的原因不是对人类白细胞、血小板特异性或 ABO 抗原的同种免疫反应的结果，而是血小板的隔离和消耗所致。本综述总结了导致血小板输注无效的临床因素，并重点介绍了最近描述导致这一临床问题的新生物学机制的数据。
