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血小板HLA基因库数字匹配技术用于恶性肿瘤血小板输注无效患者:一例报告

Platelet HLA gene bank digital matching technology for platelet transfusion refractory patients with malignant tumors: a case report.

作者信息

Gao Xiang, Li Jianhua, Ni Xiuwen, Wang Lijun, Hu Peilin, Zhu Xiaowei

机构信息

Department of Blood Transfusion, Haining People's Hospital, Haining, Zhejiang, China.

Laboratory Department, Jiaxing Central Blood Station, Haining, Zhejiang, China.

出版信息

Front Oncol. 2024 Sep 26;14:1419485. doi: 10.3389/fonc.2024.1419485. eCollection 2024.

Abstract

The platelet human leucocyte antigen (HLA) gene bank contains the genetic information of HLA loci in a large number of blood donors. Currently, the most effective treatment for platelet transfusion refractoriness (PTR) is to evaluate the probability of antigenic mismatch by HLA genotyping of patients and to select HLA-matched donors in the gene bank through an information system. This case report describes the treatment of PTR in patients with malignant tumors using the platelet HLA gene bank digital matching technique. The analysis of individual cases will help guide transfusion strategies for such patients.

摘要

血小板人类白细胞抗原(HLA)基因库包含大量献血者HLA位点的遗传信息。目前,治疗血小板输注无效(PTR)最有效的方法是通过患者的HLA基因分型评估抗原不匹配的概率,并通过信息系统在基因库中选择HLA匹配的供体。本病例报告描述了使用血小板HLA基因库数字匹配技术治疗恶性肿瘤患者的PTR。对个别病例的分析将有助于指导此类患者的输血策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/e73451823281/fonc-14-1419485-g001.jpg

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