• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血小板HLA基因库数字匹配技术用于恶性肿瘤血小板输注无效患者：一例报告

Platelet HLA gene bank digital matching technology for platelet transfusion refractory patients with malignant tumors: a case report.

作者信息

Gao Xiang, Li Jianhua, Ni Xiuwen, Wang Lijun, Hu Peilin, Zhu Xiaowei

机构信息

Department of Blood Transfusion, Haining People's Hospital, Haining, Zhejiang, China.

Laboratory Department, Jiaxing Central Blood Station, Haining, Zhejiang, China.

出版信息

Front Oncol. 2024 Sep 26;14:1419485. doi: 10.3389/fonc.2024.1419485. eCollection 2024.

DOI:10.3389/fonc.2024.1419485
PMID:39403330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11472838/
Abstract

The platelet human leucocyte antigen (HLA) gene bank contains the genetic information of HLA loci in a large number of blood donors. Currently, the most effective treatment for platelet transfusion refractoriness (PTR) is to evaluate the probability of antigenic mismatch by HLA genotyping of patients and to select HLA-matched donors in the gene bank through an information system. This case report describes the treatment of PTR in patients with malignant tumors using the platelet HLA gene bank digital matching technique. The analysis of individual cases will help guide transfusion strategies for such patients.

摘要

血小板人类白细胞抗原（HLA）基因库包含大量献血者HLA位点的遗传信息。目前，治疗血小板输注无效（PTR）最有效的方法是通过患者的HLA基因分型评估抗原不匹配的概率，并通过信息系统在基因库中选择HLA匹配的供体。本病例报告描述了使用血小板HLA基因库数字匹配技术治疗恶性肿瘤患者的PTR。对个别病例的分析将有助于指导此类患者的输血策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/74a3943bf40f/fonc-14-1419485-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/e73451823281/fonc-14-1419485-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/7021d280b16f/fonc-14-1419485-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/793dba6bcbf7/fonc-14-1419485-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/74a3943bf40f/fonc-14-1419485-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/e73451823281/fonc-14-1419485-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/7021d280b16f/fonc-14-1419485-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/793dba6bcbf7/fonc-14-1419485-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1c7/11472838/74a3943bf40f/fonc-14-1419485-g004.jpg

相似文献

1
Platelet HLA gene bank digital matching technology for platelet transfusion refractory patients with malignant tumors: a case report.血小板HLA基因库数字匹配技术用于恶性肿瘤血小板输注无效患者：一例报告
Front Oncol. 2024 Sep 26;14:1419485. doi: 10.3389/fonc.2024.1419485. eCollection 2024.
2
[Analysis of transfusion effect of different platelet matching schemes in patients with platelet transfusion refractoriness].血小板输注无效患者不同血小板匹配方案的输血效果分析
Zhonghua Yi Xue Za Zhi. 2024 Mar 19;104(11):865-869. doi: 10.3760/cma.j.cn112137-20231204-01281.
3
Establishment of platelet donor registry improves the treatment of platelet transfusion refractoriness in Guangzhou region of China.建立血小板供者登记系统改善了中国广州地区血小板输注无效的治疗情况。
Transfus Med. 2010 Aug 1;20(4):269-74. doi: 10.1111/j.1365-3148.2010.00995.x. Epub 2010 Feb 4.
4
Methodological Study on the Establishment of HLA/HPA Gene Bank of Platelet Donors and Its Clinical Application.血小板供者HLA/HPA基因库建立的方法学研究及其临床应用
Indian J Hematol Blood Transfus. 2023 Jan;39(1):123-131. doi: 10.1007/s12288-022-01547-9. Epub 2022 May 26.
5
[Study of the platelet GP specific antibodies and HLA antibodies expression in platelet transfusion refractoriness patients].血小板输注无效患者血小板糖蛋白特异性抗体及人类白细胞抗原抗体表达的研究
Zhonghua Xue Ye Xue Za Zhi. 2010 Sep;31(9):594-8.
6
Establishment and clinical application of the HLA genotype database of platelet-apheresis donors in Suzhou.苏州单采血小板献血者HLA基因分型数据库的建立及临床应用
Heliyon. 2024 Apr 10;10(8):e29268. doi: 10.1016/j.heliyon.2024.e29268. eCollection 2024 Apr 30.
7
Efficacy of HLA virtual cross-matched platelet transfusions for platelet transfusion refractoriness in hematopoietic stem cell transplantation.HLA 虚拟交叉配型血小板输注治疗造血干细胞移植后血小板输注无效的疗效。
Transfusion. 2020 Mar;60(3):473-478. doi: 10.1111/trf.15664. Epub 2020 Jan 22.
8
Evaluation and management of platelet transfusion refractoriness.血小板输注无效的评估与处理
Blood Res. 2022 Apr 30;57(S1):6-10. doi: 10.5045/br.2022.2021229.
9
Simultaneous genotyping for human platelet antigen systems and and loci by targeted next-generation sequencing.应用靶向下一代测序技术对人类血小板抗原系统和 及 位点进行同步基因分型。
Front Immunol. 2022 Sep 29;13:945994. doi: 10.3389/fimmu.2022.945994. eCollection 2022.
10
Avatrombopag for the salvage treatment of platelet transfusion refractoriness.阿伐曲泊帕用于血小板输注无效的挽救治疗。
Ther Adv Hematol. 2024 Mar 13;15:20406207241237606. doi: 10.1177/20406207241237606. eCollection 2024.

本文引用的文献

1
Immunological platelet transfusion refractoriness: current insights from mechanisms to therapeutics.免疫性血小板输注无效：从机制到治疗的最新认识。
Platelets. 2024 Dec;35(1):2306983. doi: 10.1080/09537104.2024.2306983. Epub 2024 Feb 5.
2
Related donor platelet transfusion improves platelet transfusion refractoriness in hematological patients.相关供体血小板输注可改善血液病患者的血小板输注无效。
Front Med (Lausanne). 2023 Mar 1;10:983644. doi: 10.3389/fmed.2023.983644. eCollection 2023.
3
Comparison of platelet antibody screen, crossmatching and HLA antibody testing in patients refractory to platelet transfusions.
比较血小板抗体筛查、交叉配型和 HLA 抗体检测在血小板输注无效患者中的应用。
Transfus Apher Sci. 2023 Jun;62(3):103622. doi: 10.1016/j.transci.2022.103622. Epub 2022 Dec 10.
4
Methodological Study on the Establishment of HLA/HPA Gene Bank of Platelet Donors and Its Clinical Application.血小板供者HLA/HPA基因库建立的方法学研究及其临床应用
Indian J Hematol Blood Transfus. 2023 Jan;39(1):123-131. doi: 10.1007/s12288-022-01547-9. Epub 2022 May 26.
5
Platelet transfusion refractoriness and anti-HLA immunization.血小板输注无效和抗 HLA 免疫。
Transfusion. 2021 Jun;61(6):1700-1704. doi: 10.1111/trf.16358. Epub 2021 Mar 11.
6
Incidence and impact of allele-specific anti-HLA antibodies and high-resolution HLA genotyping on assessing immunologic compatibility.等位基因特异性抗 HLA 抗体和高分辨率 HLA 基因分型对评估免疫相容性的影响及发生率。
Hum Immunol. 2021 Mar;82(3):147-154. doi: 10.1016/j.humimm.2021.01.002. Epub 2021 Jan 19.
7
Immune Thrombocytopenia Induced by Immune Checkpoint Inhibitors in Solid Cancer: Case Report and Literature Review.实体癌中免疫检查点抑制剂诱导的免疫性血小板减少症：病例报告与文献综述
Front Oncol. 2020 Dec 7;10:530478. doi: 10.3389/fonc.2020.530478. eCollection 2020.
8
Platelet transfusion refractoriness: how do I diagnose and manage?血小板输注无效：如何诊断和处理？
Hematology Am Soc Hematol Educ Program. 2020 Dec 4;2020(1):527-532. doi: 10.1182/hematology.2020000137.
9
Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion.非同种免疫性血小板减少症和血小板输注无效的机制。
Transfus Med Rev. 2020 Oct;34(4):242-249. doi: 10.1016/j.tmrv.2020.09.002. Epub 2020 Sep 17.
10
Evaluating the appropriateness of platelet transfusions compared with evidence-based platelet guidelines: An audit of platelet transfusions at 57 hospitals.评估血小板输注与基于证据的血小板指南的适宜性：57 家医院的血小板输注审核。
Transfusion. 2021 Jan;61(1):57-71. doi: 10.1111/trf.16134. Epub 2020 Oct 20.