Zhang Jieyu, Wang Gang
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
J Dermatol Sci. 2020 Nov;100(2):86-91. doi: 10.1016/j.jdermsci.2020.05.010. Epub 2020 May 31.
Bullous pemphigoid (BP) is a common autoimmune blistering skin disease that mainly affects elderly patients. Although BP risk is strongly influenced by age, genetic factors are also important determinants of this disease. Many genomic regions, especially in the HLA-II region, have been found to influence BP susceptibility through targeted sequencing studies. However, the relationship between non-HLA regions and BP susceptibility remains poorly understood and the identification of functional variants and key genes within these association regions remains a major challenge. In this review, we summarize the genetic predisposition to BP through an overview of the research history in this field.
大疱性类天疱疮（BP）是一种常见的自身免疫性水疱性皮肤病，主要影响老年患者。虽然BP风险受年龄的影响很大，但遗传因素也是该疾病的重要决定因素。通过靶向测序研究发现，许多基因组区域，尤其是HLA-II区域，会影响BP易感性。然而，非HLA区域与BP易感性之间的关系仍知之甚少，在这些关联区域内鉴定功能变异和关键基因仍然是一项重大挑战。在这篇综述中，我们通过概述该领域的研究历史，总结了BP的遗传易感性。
