环状 RNA 在病毒感染及相关疾病中的作用。
The role of circular RNAs in viral infection and related diseases.
机构信息
Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu 610052, China.
Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu 610052, China; Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
出版信息
Virus Res. 2021 Jan 2;291:198205. doi: 10.1016/j.virusres.2020.198205. Epub 2020 Oct 22.
Circular RNAs (circRNAs) are a class of non-coding RNAs with a special covalently closed circular structure, which is formed by precursor mRNA (pre-mRNA) through "back-splicing". CircRNAs are more stable than linear RNAs because they are resistant to exoribonucleases. Viral infections often cause abnormal expression of circRNAs, which could serve as novel biomarkers for the diagnosis of viral infections by detecting specific circRNAs in cells, body fluids, or tissues. CircRNAs also play a critical role in regulating host immune response and virus replication. Here, we reviewed the production and function of circRNAs, mainly focusing on their regulation on virus infection, to provide novel insights into the potential role of circRNAs as diagnostic marker or treatment targets for viral infection.
环状 RNA（circRNAs）是一类具有特殊共价闭合环状结构的非编码 RNA，由前体 mRNA（pre-mRNA）通过“反式剪接”形成。circRNAs 比线性 RNA 更稳定，因为它们能抵抗外切核酸酶。病毒感染常导致 circRNAs 的异常表达，通过检测细胞、体液或组织中特定的 circRNAs，它们可以作为病毒感染诊断的新型生物标志物。circRNAs 在调控宿主免疫反应和病毒复制方面也发挥着关键作用。在这里，我们综述了 circRNAs 的产生和功能，主要集中在它们对病毒感染的调控上，为 circRNAs 作为病毒感染的诊断标志物或治疗靶点提供新的见解。
Zotero 插件