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隐藏的RNA密码:RNA表观转录组在病毒感染背景下的意义

The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections.

作者信息

Ribeiro Diana Roberta, Nunes Alexandre, Ribeiro Daniela, Soares Ana Raquel

机构信息

Department of Medical Sciences, iBiMED-Institute of Biomedicine, University of Aveiro, Aveiro, Portugal.

出版信息

Front Genet. 2023 Aug 1;14:1245683. doi: 10.3389/fgene.2023.1245683. eCollection 2023.

Abstract

Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms. Here, we discuss how specific RNA modifications, in either host or viral RNA molecules, impact the virus-life cycle and host antiviral responses, highlighting the potential of targeting the RNA epitranscriptome for novel antiviral therapies.

摘要

新出现的证据凸显了RNA表观转录组在病毒感染过程中的多方面作用。通过调节病毒和宿主RNA的修饰格局,病毒增强其传播并逃避宿主监测机制。在此,我们讨论宿主或病毒RNA分子中的特定RNA修饰如何影响病毒生命周期和宿主抗病毒反应,强调针对RNA表观转录组开发新型抗病毒疗法的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a0d/10443596/ffc85e36ddd7/fgene-14-1245683-g001.jpg

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