分子印迹聚合物组分比对分析性能的影响。

Effect of the Molecularly Imprinted Polymer Component Ratio on Analytical Performance.

机构信息

Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University.

出版信息

Chem Pharm Bull (Tokyo). 2020;68(11):1013-1024. doi: 10.1248/cpb.c20-00551.

Abstract

Molecular imprinting technology is a new analytical method that is highly selective and specific for certain analytes in artificial receptor design. The renewal possibilities of this technology make it an ideal material for sundry application fields. Molecularly imprinted polymers (MIPs) are polymeric matrices that have molecules printed on their surfaces; these surfaces can chemically interact with molecules or follow the pattern of the available template cavities obtained using imprinting technology. A MIP is useful for separating and analysing complex samples, such as biological fluids and environmental samples, because it is a strong analytical recognition element that can mimick natural recognition entities like biological receptors and antibodies. The MIP components consist of the target template, functional monomer, crosslinker, polymerisation initiator, and porogen. The effectiveness and selectivity of a MIP are greatly influenced by variations in the components. This review will provide an overview of the effect of MIP component ratio on analytical performance to each target analyte; it will also provide a strategy to obtain the best MIP performance. For every MIP, each template : monomer : crosslinker ratio shows a distinct performance for a specific analyte. The effects of the template : monomer : crosslinker ratio on a MIP's analytical performances-measured by the imprinting factor, sorbent binding capacity, and sorbent selectivity-are briefly outlined.

摘要

分子印迹技术是一种新的分析方法,在人工受体设计中对某些分析物具有高度的选择性和特异性。该技术的更新可能性使其成为各种应用领域的理想材料。分子印迹聚合物(MIPs)是在其表面上印刷分子的聚合基质;这些表面可以与分子发生化学相互作用,或者遵循使用印迹技术获得的可用模板腔的模式。MIP 可用于分离和分析复杂的样品,如生物流体和环境样品,因为它是一种强大的分析识别元素,可以模拟生物受体和抗体等天然识别实体。MIP 的组成部分包括目标模板、功能单体、交联剂、聚合引发剂和致孔剂。MIP 的成分变化极大地影响其有效性和选择性。本综述将概述 MIP 成分比例对每种目标分析物分析性能的影响;它还将提供获得最佳 MIP 性能的策略。对于每个 MIP,每个模板:单体:交联剂的比例对于特定的分析物表现出不同的性能。简要概述了模板:单体:交联剂比例对 MIP 分析性能的影响,这些性能通过印迹因子、吸附剂结合容量和吸附剂选择性来衡量。

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