Ward J
Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance 90509.
Pediatr Infect Dis J. 1987 Aug;6(8):799-803. doi: 10.1097/00006454-198708000-00041.
PRP-protein conjugate vaccines may prove to be a prototype of a new generation of bacterial vaccines for the prevention of diseases caused by encapsulated bacteria, such as pneumococci, meningococci and Group B streptococci, as well as Hib. These diseases often strike the very young, the very old and individuals with compromised immunity. These vaccines have been "engineered" to maximize immune recognition and response. It is hoped that these vaccines will be adequate to control or possibly eradicate Hib and other invasive bacterial diseases. For high risk populations unable to respond to the vaccines, passive prophylaxis may have a role.
PRP-蛋白质结合疫苗可能会成为新一代细菌性疫苗的原型，用于预防由包膜细菌引起的疾病，如肺炎球菌、脑膜炎球菌、B族链球菌以及b型流感嗜血杆菌。这些疾病常常侵袭婴幼儿、老年人以及免疫力低下的个体。这些疫苗经过“设计”以最大化免疫识别和反应。人们希望这些疫苗足以控制甚至可能根除b型流感嗜血杆菌及其他侵袭性细菌疾病。对于无法对疫苗产生反应的高危人群，被动预防可能会发挥作用。
