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用于Tachyon-II飞行时间正电子发射断层扫描仪的具有127皮秒符合时间分辨率(CTR)的正电子发射断层探测器。

PET detectors with 127 ps CTR for the Tachyon-II time-of-flight PET scanner.

作者信息

Xie Siwei, Zhang Xi, Peng Hui, Yang Jingwu, Huang Qiu, Xu Jianfeng, Peng Qiyu

机构信息

State Key Lab of Digital Manufacturing Equipment & Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, China.

School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai 200025, China.

出版信息

Nucl Instrum Methods Phys Res A. 2019 Jul 21;933:48-55. doi: 10.1016/j.nima.2019.03.083. Epub 2019 Apr 11.

Abstract

The signal-to-noise ratio (SNR) of the reconstructed image of Positron Emission Tomography (PET) can be improved by the timing measurement. In this article, we designed, fabricated and tested 32 time-of-flight (TOF) detectors for the second generation of Tachyon TOF-PET scanners. The detector module consists of two arrays of 2 × 12 lutetium-yttrium oxyorthosilicate (LYSO) crystal cubes of 6 ×6× 6 mm. The discrete crystals were coupled to the 6 mm silicon photomultipliers (SiPMs) with optical glue. All the SiPM were tested for dark current. To correct the errors in the timing measurements caused by time-walk, two compensation methods (log-correction and linear-correction) based on the relationship between energy and timing information were purposed. As a comparison, the SiPM arrays coupled to 4 mm and 6 mm side crystal cube without optical glue were tested for coincidence timing resolution (CTR). The mean and standard deviations (SD) of dark current for the 1536 tested SiPMs were 12.72 +/- 1.70 μA at the bias voltage of 31.5 V and the temperature of 20 °C (±1 °C). CTR performance has increased by ~5% within a narrow energy window, and ~10% in a wide energy window by log-correction. The mean and SD of the CTR of 6 mm side crystal cube glue coupled was 126.9 +/- 3.6 ps for the 768 pairs of tested SiPMs. The detector is expected to provide a technical reference for the next generation of ultra-fast CTR commercial PET scanner using multilayer detectors.

摘要

通过定时测量可以提高正电子发射断层扫描(PET)重建图像的信噪比(SNR)。在本文中,我们设计、制造并测试了用于第二代Tachyon TOF-PET扫描仪的32个飞行时间(TOF)探测器。探测器模块由两个2×12阵列的6×6×6 mm钇正硅酸镥(LYSO)晶体立方体组成。离散晶体通过光学胶水与6 mm硅光电倍增管(SiPM)耦合。所有SiPM均测试了暗电流。为了校正由时间游动引起的定时测量误差,基于能量和定时信息之间的关系提出了两种补偿方法(对数校正和线性校正)。作为比较,测试了未使用光学胶水耦合到4 mm和6 mm边长晶体立方体的SiPM阵列的符合定时分辨率(CTR)。在31.5 V偏置电压和20°C(±1°C)温度下,1536个测试SiPM的暗电流平均值和标准差(SD)为12.72 +/- 1.70μA。通过对数校正,在窄能量窗口内CTR性能提高了约5%,在宽能量窗口内提高了约10%。对于768对测试SiPM,6 mm边长晶体立方体胶水耦合的CTR平均值和SD为126.9 +/- 3.6 ps。该探测器有望为下一代使用多层探测器的超快速CTR商用PET扫描仪提供技术参考。

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