构巢曲霉正向作用调控基因QUTA的分离与鉴定
Isolation and characterization of the positively acting regulatory gene QUTA from Aspergillus nidulans.
作者信息
Beri R K, Whittington H, Roberts C F, Hawkins A R
机构信息
Department of Genetics, University of Leicester, UK.
出版信息
Nucleic Acids Res. 1987 Oct 12;15(19):7991-8001. doi: 10.1093/nar/15.19.7991.
Abstract
The positively acting regulator gene QUTA from Aspergillus nidulans has been identified and located within a cluster of quinic acid utilisation (QUT) genes isolated within a recombinant phage lambda (lambda Q1). The DNA sequence of the QUTA gene reveals a single uninterrupted reading frame coding for a protein of mw 90.416 Kd. The QUTA protein sequence has a protein motif in the form of a putative "DNA finger" that shows strong homology to other such motifs in the GAL4, PPR1, ARGRII, LAC9 and QA1F regulatory gene products of S. cerevisiae, K. lactis and N. crassa. The data presented confirm the view deduced by genetical analysis that the QUTA gene of A. nidulans encodes a protein capable of interacting with QUT specific DNA sequences.
摘要
来自构巢曲霉的正向作用调节基因QUTA已被鉴定，并定位在一个重组λ噬菌体（λQ1）中分离出的奎尼酸利用（QUT）基因簇内。QUTA基因的DNA序列显示出一个单一的不间断阅读框，编码一个分子量为90.416 Kd的蛋白质。QUTA蛋白序列具有一种假定的“DNA指”形式的蛋白质基序，与酿酒酵母、乳酸克鲁维酵母和粗糙脉孢菌的GAL4、PPR1、ARGRII、LAC9和QA1F调节基因产物中的其他此类基序具有很强的同源性。所呈现的数据证实了遗传分析推断的观点，即构巢曲霉的QUTA基因编码一种能够与QUT特异性DNA序列相互作用的蛋白质。
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