Ren Songtao, Xie Shaohua, Li Xuri, Li Guofeng, Wang Yan, Liu Weidong, Wang Li
Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, People's Republic of China.
School of Medicine, Shandong University, Jinan, People's Republic of China.
Tob Induc Dis. 2020 Oct 21;18:87. doi: 10.18332/tid/127872. eCollection 2020.
Tobacco use poses a threat to the health of pregnant women and their children. Our study assessed the association between maternal exposure to secondhand smoke (SHS) during pregnancy and children's cerebral palsy (CP) in Shandong, China.
In our observational study, 5067 mother-child pairs were included from Shandong Province, China. Mothers filled in questionnaires about exposure to SHS during pregnancy. Statistical analysis and logistic regression models were built in R program to estimate the association in adjusted odds ratio (AOR) between SHS exposure during pregnancy and risk of children's CP, after adjustment for potential confounders including delivery mode and baby's birthweight.
Exposure to SHS was noted among 3663 (72.3%) of the 5067 non-smoking mothers during their pregnancy. Of the 239 CP children within the study, 192 (80.3%) were exposed to SHS during pregnancy. Children born to mothers exposed to SHS during pregnancy had a higher risk of CP (AOR=1.44; 95% CI: 1.02-2.04) than those born to non-exposed mothers, the risk increased by exposure time in the logistic regression model. The association between SHS exposure during pregnancy and CP children remained significant when adjusting for delivery mode and infant's birthweight due to their significant association with CP, with an AOR of 1.46 (95% CI: 1.13-1.91) for 1-4 days/week and 1.63 (95% CI: 1.22-2.01) for 5-7 days/week exposure to SHS.
Our study suggests that maternal exposure to secondhand smoke during pregnancy is associated with children's CP. Future preventive interventions of CP should include strategies that target the antenatal women who are exposed to SHS.
吸烟对孕妇及其子女的健康构成威胁。我们的研究评估了中国山东省孕妇孕期接触二手烟（SHS）与儿童脑瘫（CP）之间的关联。
在我们的观察性研究中，纳入了来自中国山东省的5067对母婴。母亲们填写了关于孕期接触二手烟的问卷。在R程序中建立统计分析和逻辑回归模型，以估计在调整包括分娩方式和婴儿出生体重等潜在混杂因素后，孕期接触二手烟与儿童患脑瘫风险之间的关联，以调整后的优势比（AOR）表示。
5067名不吸烟母亲中，有3663名（72.3%）在孕期接触过二手烟。在研究中的239名脑瘫儿童中，192名（80.3%）在孕期接触过二手烟。孕期接触二手烟的母亲所生子女患脑瘫的风险（AOR=1.44；95%可信区间：1.02 - 2.04）高于未接触二手烟母亲所生子女，在逻辑回归模型中，风险随接触时间增加。由于分娩方式和婴儿出生体重与脑瘫有显著关联，在对其进行调整后，孕期接触二手烟与脑瘫儿童之间的关联仍然显著，每周接触1 - 4天二手烟的AOR为1.46（95%可信区间：1.13 - 1.91），每周接触5 - 7天二手烟的AOR为1.63（95%可信区间：1.22 - 2.01）。
我们的研究表明，孕妇孕期接触二手烟与儿童脑瘫有关。未来脑瘫的预防干预措施应包括针对接触二手烟的产前妇女的策略。
