McKendrick Greer, Graziane Nicholas M
Neuroscience Graduate Program, Penn State College of Medicine, Hershey, PA, United States.
Department of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, PA, United States.
Front Behav Neurosci. 2020 Sep 29;14:582147. doi: 10.3389/fnbeh.2020.582147. eCollection 2020.
The conditioned place preference (CPP) paradigm is a well-established model utilized to study the role of context associations in reward-related behaviors, including both natural rewards and drugs of abuse. In this review article, we discuss the basic history, various uses, and considerations that are tied to this technique. There are many potential takeaway implications of this model, including negative affective states, conditioned drug effects, memory, and motivation, which are all considered here. We also discuss the neurobiology of CPP including relevant brain regions, molecular signaling cascades, and neuromodulatory systems. We further examine some of our prior findings and how they integrate CPP with self-administration paradigms. Overall, by describing the fundamentals of CPP, findings from the past few decades, and implications of using CPP as a research paradigm, we have endeavored to support the case that the CPP method is specifically advantageous for studying the role of a form of Pavlovian learning that associates drug use with the surrounding environment.
条件性位置偏爱（CPP）范式是一种成熟的模型，用于研究情境关联在与奖赏相关行为中的作用，这些行为包括自然奖赏和滥用药物。在这篇综述文章中，我们讨论了与该技术相关的基本历史、各种用途及注意事项。该模型有许多潜在的重要意义，包括负性情感状态、条件性药物效应、记忆和动机，本文均予以考虑。我们还讨论了CPP的神经生物学，包括相关脑区、分子信号级联反应和神经调节系统。我们进一步研究了我们之前的一些发现，以及它们如何将CPP与自我给药范式相结合。总体而言，通过描述CPP的基本原理、过去几十年的研究结果以及将CPP用作研究范式的意义，我们力图支持这样一种观点，即CPP方法对于研究一种将药物使用与周围环境相联系的经典条件反射学习形式的作用具有特别的优势。
