Xu Xusan, He Bin, Lin Zhixiong, Wang Xiaoxia, Yin Jingwen, Luo Xudong, Luo Shucun, Liang Chunmei, Wen Xia, Xiong Susu, Zhu Dongjian, Fu Jiawu, Lv Dong, Dai Zhun, Lin Juda, Li You, Chen Wubiao, Luo Zebin, Wang Yajun, Ma Guoda
Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Maternal and Children's Health Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Front Genet. 2020 Oct 8;11:572414. doi: 10.3389/fgene.2020.572414. eCollection 2020.
Our previous study suggested that the synapse-associated protein 97 (SAP97) gene rs3915512 polymorphism may influence neurocognition in schizophrenia patients. Neuroimaging studies have shown a possible association between cognitive function and brain activity/connectivity. Considering the poor understanding of whether the disease state and SAP97 rs3915512 polymorphism have interactive effects on brain activity/connectivity, 52 first-episode schizophrenia (FES) patients and 52 healthy controls were genotyped using blood DNA samples and underwent magnetic resonance imaging scanning. A two-way ANCOVA model was performed with rs3915512 genotypes and disease state as the between-subject factors. A significant disease × SAP97 interactive effect was found for the amplitude of low-frequency fluctuation (ALFF) in the right supplementary motor area, left rolandic opercularis area (ROC-L), and bilateral middle occipital gyrus (MOG). In addition, among auditory/visual-related brain areas, a significant interactive effect was found for resting-state functional connectivity (RSFC) between the MOG-L and bilateral superior temporal gyrus (STG) in the STG-L with ROC-R, right cuneus (Cu-R), left fusiform (Fu-L), and left lingual gyrus (LG-L). Positive correlations were found between ALFF in the ROC-L and motor speed scores, between RSFC in the STG-L and LG-L and between Brief Assessment of Cognition in Schizophrenia verbal memory scores in FES. The SAP97 rs3915512 polymorphism may affect neurocognitive function in patients with schizophrenia by changing the brain activity and connectivity of auditory/visual-related brain areas.
我们之前的研究表明，突触相关蛋白97（SAP97）基因rs3915512多态性可能影响精神分裂症患者的神经认知。神经影像学研究显示认知功能与大脑活动/连接之间可能存在关联。鉴于对疾病状态和SAP97 rs3915512多态性是否对大脑活动/连接具有交互作用了解不足，我们使用血液DNA样本对52例首发精神分裂症（FES）患者和52名健康对照进行基因分型，并进行磁共振成像扫描。以rs3915512基因型和疾病状态作为组间因素，进行双向协方差分析模型。在右侧辅助运动区、左侧罗兰岛盖区（ROC-L）和双侧枕中回（MOG）发现疾病×SAP97交互作用对低频振幅（ALFF）有显著影响。此外，在听觉/视觉相关脑区中，在左侧枕中回（MOG-L）与左侧颞上回（STG-L）和右侧罗兰岛盖区（ROC-R）、右侧楔叶（Cu-R）、左侧梭状回（Fu-L）和左侧舌回（LG-L）之间的静息态功能连接（RSFC）发现显著的交互作用。在FES患者中，ROC-L中的ALFF与运动速度评分之间、STG-L和LG-L中的RSFC之间以及精神分裂症认知简短评估言语记忆评分之间发现正相关。SAP97 rs3915512多态性可能通过改变听觉/视觉相关脑区的大脑活动和连接来影响精神分裂症患者的神经认知功能。
