Tahirou I, Zara M O, Moustapha M L, Kamayé M, Mahamadou D, Ibrahim A, Daou M, Soumana A, Ibrahim M L
Faculté de Science de la Santé de l'Université de Niamey, Niger.
Maternité Issaka Gazobi de Niamey, Niger.
Int J Pediatr. 2020 Oct 17;2020:7802560. doi: 10.1155/2020/7802560. eCollection 2020.
Congenital malaria is a serious and common infection in tropical Africa. It has multiple consequences on the newborn and the mother.
The objective of this study is to calculate the prevalence of congenital malaria, describe its clinical signs, and analyze its associated factors. . It is a cross-sectional and prospective study, conducted at Issaka Gazobi Maternity of Niamey, from June 1 to November 30, 2017. The diagnosis was made by microscopy of a thick and thin blood smear of mother, newborn, and umbilical cord.
Two hundred and forty-nine (249) consecutive newborn/mother pairs were included. The prevalence of congenital malaria infection was 26.51% (66/249) with a parasite density of 101 P/l (SD: 47.3; [80; 320]). The prevalence of congenital malaria disease was 14.06% (35/249) with a parasite density of 108 P/l (SD: 32.6; [40; 200]. All patients were infected with 43% (18/35) of neonates had hyperthermia and did not have a sucking reflex, 8.5% (3/35) were anaemic, 11.42% (4/35) had convulsed, 20% (7/35) had a coma, and 45.71% (16/35) had a low birth weight. No deaths were recorded, and only the nonuse of bed nets was significantly associated with congenital malaria ( = 0.04).
In Niger, one out of four newborns is infected with Infection can progress to congenital malaria disease. The use of mosquito nets and intermittent preventive treatment would reduce the incidence of congenital malaria.
先天性疟疾在热带非洲是一种严重且常见的感染。它对新生儿和母亲有多种影响。
本研究的目的是计算先天性疟疾的患病率，描述其临床症状，并分析其相关因素。这是一项横断面前瞻性研究，于2017年6月1日至11月30日在尼亚美伊萨卡·加佐比妇产医院进行。诊断通过对母亲、新生儿和脐带的厚薄血涂片进行显微镜检查。
纳入了249对连续的新生儿/母亲对。先天性疟疾感染的患病率为26.51%（66/249），寄生虫密度为101个/升（标准差：47.3；[80；320]）。先天性疟疾疾病的患病率为14.06%（35/249），寄生虫密度为108个/升（标准差：32.6；[40；200]）。所有患者均被感染，43%（18/35）的新生儿有高热且无吸吮反射，8.5%（3/35）贫血，11.42%（4/35）惊厥，20%（7/35）昏迷，45.71%（16/35）出生体重低。未记录到死亡病例，只有未使用蚊帐与先天性疟疾有显著关联（P = 0.04）。
在尼日尔，四分之一的新生儿感染先天性疟疾。感染可发展为先天性疟疾疾病。使用蚊帐和间歇性预防性治疗可降低先天性疟疾的发病率。
