Qiu Tingting, Liang Shuyao, Dabbous Monique, Wang Yitong, Han Ru, Toumi Mondher
Public Health Department, Aix Marseille University, Marseille Cedex 05, France.
J Mark Access Health Policy. 2020 Oct 8;8(1):1818446. doi: 10.1080/20016689.2020.1818446.
China has managed to control the coronavirus disease (COVID-19) with confinement measurements and treatment strategies, while other countries are struggling to contain the spread. This study discusses the guidelines related to COVID-19 in China in order to provide important references for other countries in the fight against COVID-19. Chinese guidelines relevant to COVID-19 were systematically searched via the China National Knowledge Infrastructure database, YiMaiTong database, and World Health Organization (WHO) COVID-19 database on March 20, 2020. Guideline information was extracted, including date of publication, source, objectives and the target population. Guidelines specific to the pharmacological treatment of COVID-19 were further investigated to identify the types of antivirus drugs recommended and to report on how treatment recommendations for COVID-19 have evolved overtime. A total of 100 guidelines were identified, of which 74 were national guidelines and 26 were regional guidelines. The scope of included guidelines consisted of: the diagnosis and treatment of COVID-19, the management of hospital departments and specific diseases during the outbreak of COVID-19. Fifty-one of the included guidelines targeted overall COVID-19 patients, while the remaining guidelines concentrated on special patient populations (i.e. geriatric population, pediatric population, and pregnant population) or patients with coexisting diseases. Fifteen guidelines focused on the pharmacological treatments for all COVID-19 patients. Interferon, Lopinavir/Ritonavir, Ribavirin, Chloroquine, and Umifenovir represented the most recommended antivirus drugs. Among them, 7 Chinese guidelines have recommended Chloroquine Phosphate or Hydroxychloroquine for the treatment of COVID-19. : China has generated a plethora of guidelines covering almost all aspects of COVID-19. Chloroquine, as one widely affordable treatment, was recommended by Chinese national guidelines and provincial guidelines. Considering the continuous debates around Chloroquine, confirmatory studies with robust methodology are awaited to address the unanswered questions on its potential benefits and risks on COVID-19.
中国通过隔离措施和治疗策略成功控制了冠状病毒病(COVID-19),而其他国家仍在努力遏制疫情蔓延。本研究探讨中国有关COVID-19的指南,以便为其他国家抗击COVID-19提供重要参考。2020年3月20日,通过中国知网数据库、医脉通数据库和世界卫生组织(WHO)COVID-19数据库系统检索了中国与COVID-19相关的指南。提取了指南信息,包括发布日期、来源、目标和目标人群。进一步研究了COVID-19药物治疗的具体指南,以确定推荐的抗病毒药物类型,并报告COVID-19治疗建议如何随时间演变。共识别出100项指南,其中74项为国家指南,26项为地区指南。纳入指南的范围包括:COVID-19的诊断和治疗、COVID-19爆发期间医院科室管理和特定疾病。纳入的指南中有51项针对所有COVID-19患者,其余指南则集中于特殊患者群体(即老年人群体、儿童群体和孕妇群体)或合并症患者。15项指南关注所有COVID-19患者的药物治疗。干扰素、洛匹那韦/利托那韦、利巴韦林、氯喹和乌米芬ovir是最常推荐的抗病毒药物。其中,7项中国指南推荐磷酸氯喹或羟氯喹治疗COVID-19。中国已经制定了大量涵盖COVID-19几乎所有方面的指南。氯喹作为一种广泛可负担的治疗方法,被中国国家指南和省级指南推荐。考虑到围绕氯喹的持续争论,需要采用严谨方法进行确证性研究,以解决其对COVID-19潜在益处和风险方面未解决的问题。
J Mark Access Health Policy. 2020-10-8
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