Department of Neurology, Columbia University Medical Center, New York, NY, US.
Initiative for Columbia Ataxia and Tremor, Columbia University Medical Center, New York, NY, US.
Tremor Other Hyperkinet Mov (N Y). 2020 Oct 16;10:43. doi: 10.5334/tohm.550.
The cerebellum has recently been identified to have a key role in reward processing, and individuals with ataxia have been found to be more impulsive and compulsive as part of cerebellum-related cognitive and behavioral disturbances.
We reported five individuals with cerebellar ataxia who demonstrate impulsive and compulsive behaviors, including hobbyism, gambling, and compulsive medication use, to illustrate that these symptoms can be highly disabling.
These five cases provide examples of behavioral symptoms in cerebellar ataxia. Further investigations of the pathomechanism of these symptoms will advance our understanding of the cerebellum in cognition and behavior.
小脑最近被确定在奖励处理中具有关键作用，并且已经发现共济失调患者表现出冲动和强迫行为，这是与小脑相关的认知和行为障碍的一部分。
我们报告了五名患有小脑共济失调的患者，他们表现出冲动和强迫行为，包括爱好、赌博和强迫性用药，以说明这些症状可能非常致残。
这五个病例提供了小脑共济失调行为症状的例子。进一步研究这些症状的发病机制将增进我们对小脑在认知和行为中的理解。
