射波刀治疗包括Dorello管在内的颅底岩斜区转移瘤：10例报告
CyberKnife Radiotherapy for Skull Base Petroclival Metastases Including Dorello's Canal: Report of 10 Cases.
作者信息
Miyazaki Shinichiro, Harada Yuko, Sasaki Yusuke, Fukushima Takanori
机构信息
CyberKnife Center, Shin-Yurigaoka General Hospital, Kawasaki, JPN.
Neurosurgery, Tokyo General Hospital, Tokyo, JPN.
出版信息
Cureus. 2020 Sep 28;12(9):e10692. doi: 10.7759/cureus.10692.
Skull base petroclival metastases cause diplopia due to abducens nerve palsy. Diplopia is visually disabling, and skull base metastasis is extremely difficult to treat even with microscopic surgery. However, stereotactic radiotherapy with CyberKnife (Accuray Incorporated, Sunnyvale, California) has been very successful in 10 cases. As the abducens nerve runs through Dorello's canal in the skull base, the radiation dose and fraction were adjusted to avoid damage to the nerve. Since these metastases are not located inside the brain but in the skull base, contrast magnetic resonance imaging (MRI) combined with fluorodeoxyglucose-positron emission tomography (FDG-PET) was essential to detect the cancers.
颅底岩斜区转移瘤可因展神经麻痹导致复视。复视会导致视力障碍，即便采用显微手术，颅底转移瘤也极难治疗。然而，使用射波刀（Accuray Incorporated，加利福尼亚州桑尼维尔）进行立体定向放射治疗已在10例患者中取得了非常成功的效果。由于展神经穿过颅底的Dorello管，因此需调整放射剂量和分割方式以避免损伤该神经。由于这些转移瘤并非位于脑内而是在颅底，因此对比磁共振成像（MRI）联合氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）对于检测癌症至关重要。
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