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对采用或未采用鼻牙槽骨塑形术治疗的非综合征性腭裂鼻进行的对比摄影回顾性分析

Comparative Photographic, Retrospective Analysis of Nonsyndromic Cleft Noses Treated with or without NAM.

作者信息

Wolff Klaus-Dietrich, Grill Florian D, Ritschl Lucas M

机构信息

Department of Oral and Maxillofacial Surgery, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.

出版信息

Plast Reconstr Surg Glob Open. 2020 Sep 23;8(9):e3045. doi: 10.1097/GOX.0000000000003045. eCollection 2020 Sep.

Abstract

BACKGROUND

Long-term results and efficacy of nasoalveolar molding (NAM) on the perinasal region are reported controversially in the literature. With this study, we demonstrate our experiences, contribute to the ongoing discussion, and describe our decision-making when NAM is indicated or not.

METHODS

Conventional pre- and postinterventional photographs of patients with nonsyndromic unilateral and bilateral cleft lip and palate (UCLP and BCLP) were analyzed. The 2 independent raters were blinded to therapy (NAM versus non-NAM), and 7 parameters were measured. Intraclass correlation coefficient for intra- and interrater reliability was calculated. The Mann-Whitney U test was performed to compare therapy- and appearance-matched pairs. Finally, 30 specialists in cranio-maxillofacial surgery performed a subjective, blinded rating of matched NAM and non-NAM cases.

RESULTS

Thirty-six patients, 16 UCLP and 20 BCLP, were enrolled. The intraclass correlation coefficients for intra- and interrater reliability were excellent for all measurements, except for nasal sill (0.77 intrarater and 0.80 interrater). Height-to-width ratio ( = 0.012) was significantly different in the comparison of non-NAM and NAM-treated severe cases with UCLP. Thirty blinded raters evaluated NAM-treated cases with severe UCLP better than matched non-NAM cases. Non-NAM-treated cases with moderate UCLP and BCLP were rated better than matched NAM cases.

CONCLUSIONS

Children with severe UCLP may benefit from NAM therapy in the sense of better symmetry and a more homogenous appearance. Patients with moderate UCLP and BCLP did not benefit, and the risk of the burden of care increased.

摘要

背景

鼻牙槽塑形术(NAM)对鼻周区域的长期效果和疗效在文献中的报道存在争议。通过本研究,我们展示我们的经验,为正在进行的讨论做出贡献,并描述我们在决定是否采用NAM时的决策过程。

方法

分析非综合征性单侧和双侧唇腭裂(UCLP和BCLP)患者的常规干预前和干预后照片。两名独立评估者对治疗方式(NAM与非NAM)不知情,并测量了7个参数。计算评估者内部和评估者间可靠性的组内相关系数。采用曼-惠特尼U检验比较治疗匹配和外观匹配的配对。最后,30名颅颌面外科专家对匹配的NAM和非NAM病例进行了主观的、不知情的评分。

结果

纳入36例患者,其中16例UCLP和20例BCLP。除鼻槛外(评估者内部为0.77,评估者间为0.80),所有测量的评估者内部和评估者间可靠性的组内相关系数均极佳。在比较非NAM和NAM治疗的严重UCLP病例时,高宽比( = 0.012)有显著差异。30名不知情的评估者对严重UCLP的NAM治疗病例的评价优于匹配的非NAM病例。非NAM治疗的中度UCLP和BCLP病例的评分优于匹配的NAM病例。

结论

严重UCLP患儿可能从NAM治疗中受益,表现为对称性更好、外观更均匀。中度UCLP和BCLP患者未受益,且护理负担风险增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eacf/7544263/82a8e78fc07b/gox-8-e3045-g001.jpg

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