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近期植入脊髓刺激器的新冠肺炎患者中白细胞介素-6驱动的细胞因子风暴的临床管理：一例报告

Clinical Management of Il-6 Driven Cytokine Storm Related to COVID-19 in a Patient with Recent Spinal Cord Stimulator Implants: A Case Report.

作者信息

Papa Alfonso, Di Dato Maria Teresa, Buonavolonta Pietro, Saracco Elisabetta, Salzano Anna Maria, Casale Beniamino

机构信息

Pain Department, Monaldi Hospital Napoli, Naples, Italy.

IPAS Moleculat Immunological Therapy AO Ospedali dei Colli- Monaldi Hospital Napoli, Naples, Italy.

出版信息

Anesth Pain Med. 2020 Aug 1;10(4):e104151. doi: 10.5812/aapm.104151. eCollection 2020 Aug.

DOI:10.5812/aapm.104151
PMID:33134148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7539055/
Abstract

INTRODUCTION

In the last months of 2019, the advent of a new virus called SARS-CoV-2 caused the spread of a pandemic disease, COVID-19, that has afflicted patients with chronic pain.

CASE PRESENTATION

We describe a COVID-19 patient recently implanted with a spinal cord stimulator for FBSS, treated with Tocilizumab for cytokine storm complicating SARS-COV-2 infection. This patient developed a delayed hyperimmune reaction, causing an inflammatory reaction in the surgical pocket site, well treated with total remission. The total resolution of this local reaction occurred after the resolution of systemic COVID-19 infection by Tocilizumab.

CONCLUSIONS

We discuss the balance between damage-associated molecular patterns (DAMPs) and pathogen-recognition receptors (PRRs), and the putative role of polymorphism in the IL-6/174 position of the promoter region.

摘要

引言

2019年的最后几个月，一种名为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的新型病毒出现，导致了一场大流行病——冠状病毒病2019（COVID-19）的传播，该病困扰着慢性疼痛患者。

病例介绍

我们描述了一名近期因Failed Back Surgery Syndrome（FBSS）植入脊髓刺激器的COVID-19患者，该患者因SARS-CoV-2感染并发细胞因子风暴而接受托珠单抗治疗。该患者发生了延迟性超敏反应，导致手术切口部位出现炎症反应，经治疗完全缓解。在托珠单抗使全身性COVID-19感染消退后，这种局部反应完全消退。

结论

我们讨论了损伤相关分子模式（DAMPs）与病原体识别受体（PRRs）之间的平衡，以及启动子区域白细胞介素-6（IL-6）/174位点多态性的假定作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2586/7539055/8ace756d0c31/aapm-10-4-104151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2586/7539055/2a0302fd7e0a/aapm-10-4-104151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2586/7539055/8ace756d0c31/aapm-10-4-104151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2586/7539055/2a0302fd7e0a/aapm-10-4-104151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2586/7539055/8ace756d0c31/aapm-10-4-104151-g002.jpg

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