心脏直视手术后硒微量元素与患者预后的关系
Relationship Between Selenium Trace and Patient Outcome After Open-Heart Surgery.
作者信息
Eslami Gohar, Salehi Roya, Samaee Hamidreza, Habibi Vallialah, Shokrzadeh Mohammad, Moradimajd Parisa
机构信息
Departement of Clinical Pharmacy, Faculty of Pharmacy, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Departement of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Anesth Pain Med. 2020 Aug 9;10(4):e105895. doi: 10.5812/aapm.105895. eCollection 2020 Aug.
BACKGROUND
Acute stress response to heart surgery can cause major morbidity in patients. The trace of selenium is useful for preventing heart damage. Although the trend of selenium changes is of high importance for body balance, the usefulness of routine use and effectiveness of this element for patients under open-heart surgery is still unclear.
OBJECTIVES
This study aimed at assessing serum selenium level before and after open-heart surgery and the relationship between selenium trace and patient outcome.
METHODS
This prospective analytical study was performed on 100 patients undergoing open-heart surgery using cardiopulmonary bypass (CPB). In all patients, the serum level was measured at a predetermined time (before surgery and one and two days after surgery). Then, the relationship between serum selenium and patient outcome was assessed.
RESULTS
The mean serum selenium level in patients on admission was 72.90 ± 14.62 μg/L, one day after surgery was 71.20 ± 15.84 μg/L, and two days after surgery was 71.54 ± 15.97 μg/L. Serum selenium levels were inversely and significantly associated with age (r = -0.183; P = 0.034, 013) duration of surgery (r = -221 and P = 0.014), duration of intensive care unit stay (r = 0.204, P = 0.021), and duration of CPB (r = 0.223, P = 013).
CONCLUSIONS
Based on this study's results, a low level of selenium can affect patients' outcomes after open-heart surgery.
背景
心脏手术的急性应激反应可导致患者出现严重并发症。硒元素有助于预防心脏损伤。尽管硒含量变化趋势对身体平衡至关重要，但对于接受心脏直视手术的患者，常规使用该元素的有效性仍不明确。
目的
本研究旨在评估心脏直视手术前后患者的血清硒水平，以及硒含量与患者预后的关系。
方法
本前瞻性分析研究对100例接受体外循环心脏直视手术的患者进行。在所有患者中，于预定时间（术前、术后1天和2天）测量血清水平。然后，评估血清硒与患者预后的关系。
结果
患者入院时血清硒平均水平为72.90±14.62μg/L，术后1天为71.20±15.84μg/L，术后2天为71.54±15.97μg/L。血清硒水平与年龄呈显著负相关（r = -0.183；P = 0.034，01;3）、手术持续时间（r = -221，P = 0.014）、重症监护病房停留时间（r = 0.204，P = 0.021）和体外循环持续时间（r = 0.223，P = 01;3）。
结论
基于本研究结果，低硒水平会影响心脏直视手术后患者的预后。
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