氯胺酮与曲马多治疗急性疼痛的比较；一项系统评价
Comparison of Ketamine and Tramadol in Management of Acute Pain; a Systematic Review.
作者信息
Naghipour Bahman, Pouraghaei Mahboub, Tabatabaey Ali, Arjmand Allahveirdy, Faridaalaee Gholamreza
出版信息
Arch Acad Emerg Med. 2020 Aug 23;8(1):e68. eCollection 2020.
INTRODUCTION
Management of pain is an important part of care in the emergency department (ED). Tramadol and Ketamine have both been introduced as alternatives to opioids in the ED and post-operative setting. In this study, we conducted a systematic review of available literature to compare the analgesic efficacy, and side effect profile of these two medications in management of severe acute pain.
METHODS
This is a systematic review based on the PRISMA protocol. In this study, peer-reviewed papers published by March 3, 2020, which compared analgesic effects of tramadol and ketamine in management of acute pain were included.
RESULT
The initial search of online databases identified 2826 non-duplicate records. Finally, three papers available in full text were analyzed for study quality. The results show that ketamine has consistently been shown to be superior to tramadol for pain control and causes fewer significant side effects.
CONCLUSION
Results of this review show that low-dose ketamine is more effective than tramadol in pain control, while causing fewer side effects.
引言
疼痛管理是急诊科护理的重要组成部分。曲马多和氯胺酮都已被引入急诊科和术后环境中作为阿片类药物的替代品。在本研究中，我们对现有文献进行了系统评价，以比较这两种药物在治疗严重急性疼痛时的镇痛效果和副作用情况。
方法
这是一项基于PRISMA协议的系统评价。在本研究中，纳入了截至2020年3月3日发表的、比较曲马多和氯胺酮在急性疼痛管理中镇痛效果的同行评审论文。
结果
对在线数据库的初步检索识别出2826条非重复记录。最后，对三篇全文可用的论文进行了研究质量分析。结果表明，氯胺酮在疼痛控制方面一直被证明优于曲马多，且引起的显著副作用更少。
结论
本综述结果表明，低剂量氯胺酮在疼痛控制方面比曲马多更有效，同时副作用更少。
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