Jonkman Kelly, Dahan Albert, van de Donk Tine, Aarts Leon, Niesters Marieke, van Velzen Monique
Department of Anesthesiology, Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, Netherlands.
F1000Res. 2017 Sep 20;6. doi: 10.12688/f1000research.11372.1. eCollection 2017.
The efficacy of the -methyl-D-aspartate receptor antagonist ketamine as an analgesic agent is still under debate, especially for indications such as chronic pain. To understand the efficacy of ketamine for relief of pain, we performed a literature search for relevant narrative and systematic reviews and meta-analyses. We retrieved 189 unique articles, of which 29 were deemed appropriate for use in this review. Ketamine treatment is most effective for relief of postoperative pain, causing reduced opioid consumption. In contrast, for most other indications (that is, acute pain in the emergency department, prevention of persistent postoperative pain, cancer pain, and chronic non-cancer pain), the efficacy of ketamine is limited. Ketamine's lack of analgesic effect was associated with an increase in side effects, including schizotypical effects.
N-甲基-D-天冬氨酸受体拮抗剂氯胺酮作为一种镇痛剂的疗效仍存在争议，尤其是在慢性疼痛等适应症方面。为了解氯胺酮缓解疼痛的疗效，我们对相关的叙述性综述、系统评价和荟萃分析进行了文献检索。我们检索到189篇独特的文章，其中29篇被认为适合用于本综述。氯胺酮治疗对缓解术后疼痛最有效，可减少阿片类药物的用量。相比之下，对于大多数其他适应症（即急诊科的急性疼痛、预防持续性术后疼痛、癌痛和慢性非癌性疼痛），氯胺酮的疗效有限。氯胺酮缺乏镇痛效果与副作用增加有关，包括类精神分裂症效应。
