调节微环境以治疗胶质母细胞瘤。
Modulating microenvironments for treating glioblastoma.
作者信息
Roberts LaDeidra Monet, Munson Jennifer
机构信息
Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
出版信息
Curr Tissue Microenviron Rep. 2020 Sep;1(3):99-111. doi: 10.1007/s43152-020-00010-z. Epub 2020 Aug 13.
PURPOSE OF REVIEW
This review focuses on the development and progression of glioblastoma through the brain and glioma microenvironment. Specifically we highlight how the tumor microenvironment contributes to the hallmarks of cancer in hopes of offering novel therapeutic options and tools to target this microenvironment.
RECENT FINDINGS
The hallmarks of cancer, which represent elements of cancers that contribute to the disease's malignancy, yet elements within the brain tumor microenvironment, such as other cellular types as well as biochemical and biophysical cues that can each uniquely affect tumor cells, have not been well-described in this context and serve as potential targets for modulation.
SUMMARY
Here, we highlight how the brain tumor microenvironment contributes to the progression and therapeutic response of tumor cells. Specifically, we examine these contributions through the lens of Hanahan & Weinberg's Hallmarks of Cancer in order to identify potential novel targets within the brain that may offer a means to treat brain cancers, including the deadliest brain cancer, glioblastoma.
综述目的
本综述聚焦于胶质母细胞瘤在脑内的发生发展以及胶质瘤微环境。具体而言，我们着重探讨肿瘤微环境如何促成癌症的特征，以期提供针对该微环境的新型治疗选择和工具。
最新发现
癌症的特征代表了促成疾病恶性程度的癌症要素，但脑肿瘤微环境中的要素，如其他细胞类型以及各自能独特影响肿瘤细胞的生化和生物物理信号，在此背景下尚未得到充分描述，可作为潜在的调控靶点。
总结
在此，我们强调脑肿瘤微环境如何促成肿瘤细胞的进展和治疗反应。具体而言，我们通过Hanahan和Weinberg的《癌症的特征》这一视角来审视这些贡献，以确定脑内潜在的新型靶点，这些靶点可能提供治疗脑癌（包括最致命的脑癌——胶质母细胞瘤）的方法。
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