成胶质细胞瘤周细胞通过产生骨桥蛋白促进血管生成。
Glioma Pericytes Promote Angiogenesis by Producing Periostin.
机构信息
Tissue Microenvironment Laboratory, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Laboratory of Neuropharmacology and Neurochemistry, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.
出版信息
Cell Mol Neurobiol. 2022 Apr;42(3):557-564. doi: 10.1007/s10571-020-00975-3. Epub 2020 Oct 3.
Abstract
Glioma is the prevalent aggressive primary brain tumor, with a very poor prognosis. The absence of advanced understanding of the roles played by the cells within the glioma microenvironment limits the development of effective drugs. A recent study indicates that periostin expressed by pericytes is crucial for glioma angiogenesis. Here, we describe succinctly the results and implications of this discovery in what we know about pericytes within the glioma microenvironment. The emerging knowledge from this work will benefit the development of therapies for gliomas.
摘要
神经胶质瘤是常见的侵袭性原发性脑肿瘤，预后极差。由于对神经胶质瘤微环境中细胞所起作用的认识不足，限制了有效药物的开发。最近的一项研究表明，周细胞表达的骨粘连蛋白对于神经胶质瘤血管生成至关重要。在这里，我们简要描述了这一发现的结果和意义，以及我们对神经胶质瘤微环境中周细胞的了解。这项工作产生的新知识将有助于神经胶质瘤治疗方法的发展。
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