Haseoka Takashi, Inagaki Risako, Kurata Kentaro, Arai Shinji, Takagi Yuri, Suzuki Hiroko, Hikoya Akiko, Nishimura Kasumi, Hotta Yoshihiro, Sato Miho
Department of Ophthalmology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu-shi, Higashi-ku, Shizuoka, 431-3192, Japan.
Shizuoka Children's Hospital, Shizuoka, Japan.
Jpn J Ophthalmol. 2021 Jan;65(1):23-29. doi: 10.1007/s10384-020-00782-9. Epub 2020 Nov 2.
To report the diagnosis of three childhood patients with blue-cone monochromatism (BCM) using S-cone electroretinograms (ERG) recorded with RETeval Complete.
Prospective clinical study.
We examined three boys initially suspected of having rod monochromatism. S-cone ERG was performed with red background and blue flashed light stimulation using two different intensities: 0.25 cd × s/m and 1 cd × s/m.
Case 1 was a 12-year-old boy with a visual acuity of 0.1 OU. Case 2 was an 8-year-old boy with a visual acuity of 0.3 OD and 0.2 OS. Both cases showed a myopic fundus and nystagmus without any other ocular abnormalities. Case 3 was a 6-year-old boy with a visual acuity of 0.3 OD and 0.4 OS. He also showed myopic fundus changes, but nystagmus was not observed. Rod and maximal responses recorded with RETeval were likely to be within normal range; however, cone responses were absent in all cases. S-cone ERGs showed positive responses at 40 ms with 0.25 cd × s/m intensity in Case 2, and at approximately 30-40 ms with 1.0 cd × s/m intensity in all three cases. These ERG findings led to a diagnosis of BCM.
S-cone ERG of RETeval was helpful in diagnosing with minimal invasion BCM in childhood patients.
报告使用RETeval Complete记录的S - 视锥细胞视网膜电图（ERG）对三名患有蓝锥单色视（BCM）的儿童患者进行诊断的情况。
前瞻性临床研究。
我们检查了三名最初怀疑患有视杆单色视的男孩。使用红色背景和蓝色闪光刺激，以两种不同强度（0.25 cd×s/m和1 cd×s/m）进行S - 视锥细胞ERG检查。
病例1是一名12岁男孩，双眼视力为0.1。病例2是一名8岁男孩，右眼视力为0.3，左眼视力为0.2。这两个病例均表现为近视眼底和眼球震颤，无任何其他眼部异常。病例3是一名6岁男孩，右眼视力为0.3，左眼视力为0.4。他也表现出近视眼底改变，但未观察到眼球震颤。用RETeval记录的视杆细胞和最大反应可能在正常范围内；然而，所有病例的视锥细胞反应均缺失。S - 视锥细胞ERG在病例2中，强度为0.25 cd×s/m时，在40毫秒出现阳性反应；在所有三个病例中，强度为1.0 cd×s/m时，在大约30 - 40毫秒出现阳性反应。这些ERG结果导致了BCM的诊断。
RETeval的S - 视锥细胞ERG有助于以微创方式诊断儿童患者的BCM。
