Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
Eur J Ophthalmol. 2022 Jan;32(1):NP191-NP193. doi: 10.1177/1120672120963452. Epub 2020 Nov 2.
Idiopathic Brown's syndrome is a restrictive strabismus of the superior oblique tendon that often presents in pediatric populations and rarely occurs in adults.
We present here a case of a 41-year-old man with an idiopathic left Brown's syndrome that recurred after presenting with similar symptoms 14 years prior that was originally treated with oral corticosteroids. This patient had a negative work up for connective tissue disease and only exhibited subtle left trochlear thickening on orbital MRI with contrast. Since he had a good response to oral corticosteroids in the past, this repeat occurrence was treated with oral Prednisone and he promptly responded. His double vision resolved within 2 weeks and he continued to have a normal examination 6 months after presentation.
We suspect this case was related to a subclinical inflammatory process resulting in the MRI findings and response to steroids. This case demonstrates that idiopathic Brown's syndrome can recur more than a decade later in adults and oral corticosteroids are an effective treatment option even in the absence of an underlying rheumatological condition.
特发性 Brown 综合征是一种上斜肌腱的限制性斜视,常见于儿科人群,在成人中很少见。
我们在此介绍一例 41 岁男性患者,其左侧特发性 Brown 综合征在 14 年前出现类似症状后复发,最初采用口服皮质类固醇治疗。该患者未发现结缔组织疾病的相关检查异常,仅在眼眶 MRI 增强扫描中显示左侧滑车轻微增厚。由于他过去对口服皮质类固醇有良好的反应,因此本次复发采用口服泼尼松治疗,他的症状迅速得到缓解。他的复视在 2 周内得到缓解,并且在就诊后 6 个月时仍保持正常检查结果。
我们怀疑该病例与亚临床炎症过程有关,导致 MRI 结果和对类固醇的反应。该病例表明,特发性 Brown 综合征在成人中可在 10 多年后复发,即使没有潜在的风湿性疾病,口服皮质类固醇也是一种有效的治疗选择。