Dental Research Cell and Biomedical Research Unit and Lab Animal Centre, Saveetha Denatal College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 600077, India.
Mol Cell Biochem. 2021 Feb;476(2):941-947. doi: 10.1007/s11010-020-03960-y. Epub 2020 Nov 2.
Arthritis is a kind of autoimmune disease, which includes many circumstances that affect joints, the tissues surrounding the joints, and other connective tissues. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the common arthritis seen in many populations. Researchers have made extensive studies on all types of arthritis, novel drugs are being developed by many laboratories, but yet no treatment option is available for these diseases and need new insight into the molecular pathways and pathophysiology of all types of arthritis. MicroRNAs (miRNAs), a class of non-coding RNAs, have shown to be played a plenty of roles in both a suppressive and a promoting role in disease pathogenesis and progression. Among the classes of microRNAs, miR-21 is a widespread miRNA commonly upregulated in many diseases and suggesting that it plays an important role in cell proliferation, apoptosis, and invasion. It is highly expressed in osteoclast precursors and the pro-osteoclastogenic nature of miR-21 makes it a promising candidate as a therapeutic target to treat bone-related disorders. Up to now, there are few papers that demonstrate the role of miR-21 in arthritis and related bone disorders and the number of studies related to different types of arthritis is sparse. Therefore, the main thrust of this paper is to provide an overview of the current clinical evidence and significance of miR-21 in arthritis and bone-related inflammation disorders. We summarize the important research findings surrounding the role of miR-21 and its involvement in the treatment of different types of arthritis.
关节炎是一种自身免疫性疾病，包括许多影响关节、关节周围组织和其他结缔组织的情况。骨关节炎（OA）和类风湿关节炎（RA）是许多人群中常见的关节炎。研究人员对所有类型的关节炎进行了广泛的研究，许多实验室正在开发新的药物，但这些疾病仍然没有治疗方法，需要对所有类型关节炎的分子途径和病理生理学有新的认识。微小 RNA（miRNA）是一类非编码 RNA，已被证明在疾病的发病机制和进展中发挥着抑制和促进的双重作用。在 miRNA 中，miR-21 是一种广泛表达的 miRNA，在许多疾病中都被上调，表明其在细胞增殖、凋亡和侵袭中发挥重要作用。miR-21 在破骨细胞前体中高度表达，miR-21 的促破骨细胞生成特性使其成为治疗与骨相关疾病的有前途的治疗靶点。到目前为止，很少有论文证明 miR-21 在关节炎和相关骨疾病中的作用，而且与不同类型关节炎相关的研究数量也很少。因此，本文的主要重点是提供 miR-21 在关节炎和与骨相关的炎症性疾病中的临床证据和意义的概述。我们总结了围绕 miR-21 作用及其在治疗不同类型关节炎中的参与的重要研究结果。
