Section of Dental Anesthesiology, Department of Oral and Maxillofacial Surgery and Oral Medicine, Hiroshima University Hospital.
Department of Oral and Maxillofacial Surgery.
J Craniofac Surg. 2021;32(1):273-276. doi: 10.1097/SCS.0000000000007019.
Tranexamic acid has been used to reduce intraoperative bleeding; however, its effect on anti-inflammation and the amount of drainage after orthognathic surgery is yet to be determined. Therefore, we aimed to examine the effect of tranexamic acid on intraoperative bleeding volume and operation time, amount of drainage, and anti-inflammation after orthognathic surgery. Forty healthy women who underwent bilateral sagittal split ramus osteotomy under general anesthesia participated in this study. The amount of intraoperative bleeding, the operation time, the amount of drainage, and the C-reactive protein level were compared between patients intravenously administered with tranexamic acid before surgery (before-surgery group) and those administered with the drug after surgery (after-surgery group). All data were analyzed using the Student t-test. Results were considered to be statistically significant when P < 0.05. Although no significant difference was found in the amount of drainage between the groups (P > 0.05), significant variations were detected in the amount of bleeding during surgery (before-surgery group: 161.7 ± 45.3 mL versus after-surgery group: 270.2 ± 24.0 mL; P = 0.0009), operation time (before-surgery group: 141.3 ± 16.8 min versus after-surgery group: 166.8 ± 24.9 min; P = 0.03), and postoperative C-reactive protein level (before-surgery group: 3.77 ± 0.40 mg/dL versus after-surgery group: 5.02 ± 0.75 mg/dL; P = 0.012) between the groups. In conclusion, administering tranexamic acid before surgery was found to significantly decrease bleeding, reduce operation time, and suppress postoperative inflammation.
氨甲环酸已被用于减少术中出血；然而，其在正颌手术后的抗炎作用和引流量尚不清楚。因此，我们旨在研究氨甲环酸对正颌手术后术中出血量、手术时间、引流量和抗炎的影响。40 名在全身麻醉下接受双侧下颌升支矢状劈开截骨术的健康女性参与了本研究。比较了术前静脉注射氨甲环酸的患者（术前组）和术后静脉注射氨甲环酸的患者（术后组）的术中出血量、手术时间、引流量和 C 反应蛋白水平。所有数据均采用学生 t 检验进行分析。当 P<0.05 时，结果被认为具有统计学意义。尽管两组间引流量无显著差异（P>0.05），但术中出血量（术前组：161.7±45.3 mL 与术后组：270.2±24.0 mL；P=0.0009）、手术时间（术前组：141.3±16.8 min 与术后组：166.8±24.9 min；P=0.03）和术后 C 反应蛋白水平（术前组：3.77±0.40 mg/dL 与术后组：5.02±0.75 mg/dL；P=0.012）存在显著差异。总之，术前给予氨甲环酸可显著减少出血、缩短手术时间并抑制术后炎症。
