自体牙骨移植物与辛伐他汀联合对骨愈合的影响。

Autogenous Tooth Bone Graft and Simvastatin Combination Effect on Bone Healing.

机构信息

Dentistry Faculty, Oral and Maxillofacial Department, Pamukkale University, Denizli.

Dentistry Faculty, Oral and Maxillofacial Department, Inönü University, Malatya.

出版信息

J Craniofac Surg. 2020 Nov/Dec;31(8):2350-2354. doi: 10.1097/SCS.0000000000006707.

DOI:10.1097/SCS.0000000000006707

PMID:33136889

Abstract

OBJECTIVE

Autogenous tooth bone grafts (ATGM) are materials prepared from extracted teeth and have been used for bone augmentation. These graft materials are known to have similar structures and components to bone grafts. In this sense, this study aimed to evaluate all the tooth layers mixed with simvastatin without any demineralization process effect on bone formation.

METHODS

In 60 Wistar albino rats, a standardized 6.0 m-diameter critical size bone defect was created in their calvarium. The study consists of 1 control and 4 experimental groups. In the control group (12 rats), the defects were left empty. The defects were grafted only with ATGM in Group 1, with ATGM mixed with simvastatin in Group 2, autogenous bone graft mixed with simvastatin in Group 3, and with xenogenic bone graft mixed with simvastatin in Group 4. The animals were sacrificed at the 7th and 28th days after operation.

RESULTS

PCR, micro CT and histological results show that bone formation was enhanced in the experimental groups in comparison to the control group. Group 1 and Group 2 had similar bone formation rate when compared to Group 3 and Group 4 at the 28th day after operation.

CONCLUSION

This study concludes that mineralized teeth may be used for defect reconstruction without any demineralization process. Autogenous mineralized tooth bone graft should be mixed with simvastatin for bone regeneration like other grafts.

摘要

目的

自体牙骨移植物（ATGM）是从拔出的牙齿中制备的材料，已被用于骨增量。这些移植物材料被认为具有与骨移植物相似的结构和成分。从这个意义上说，本研究旨在评估所有未经脱矿处理的牙层与辛伐他汀混合对骨形成的影响。

方法

在 60 只 Wistar 白化大鼠的颅骨上，创建了一个标准化的 6.0 毫米直径的临界尺寸骨缺损。该研究包括 1 个对照组和 4 个实验组。在对照组（12 只大鼠）中，将缺损空出。第 1 组仅用 ATGM 移植，第 2 组用 ATGM 混合辛伐他汀，第 3 组用自体骨混合辛伐他汀，第 4 组用异种骨混合辛伐他汀。在手术后第 7 天和第 28 天处死动物。