自体骨移植混合重组人血管内皮生长因子对骨再生的影响。
The Effect of Autogenous Bone Graft Mixed With Recombinant Human Vascular Endothelial Growth Factor on Bone Regeneration.
机构信息
Oral and Maxillofacial Department, Faculty of Dentistry, Pamukkale University, Denizli.
Pathology Department, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur.
出版信息
J Craniofac Surg. 2021 Sep 1;32(6):2233-2237. doi: 10.1097/SCS.0000000000007316.
INTRODUCTION
Bone regeneration depends on vascularization in the pertaining site. This study aims to investigate autogenous bone grafts mixed with recombinant human vascular endothelial growth factor (rhVEGF) effect on bone regeneration in rat mandibular bone defect.
MATERIAL METHODS
Using 32 Wistar Albino rats, our experimental study consists of 4 groups: Group1 (control group), the defect was empty; Group 2, autogenous bone graft only; Group 3, gelatin sponge plus rhVEGF applications; Group 4, autogenous bone graft plus rhVEGF applications. The rats were sacrificed on the 28th day after the operation. New bone regeneration was analyzed histologically and immunohistochemically.
RESULTS
Our histological analyses revealed that new bone regeneration in Group 3 was enhanced in comparison to Group 1 and Group 2. However, autogenous bone grafts combined with rhVEGF provided the best outcome in conjunction with the increased remodeling of the new bone.
CONCLUSIONS
In the light of our results, it can be concluded that autogenous bone grafts in combination with rhVEGF can, potentially, enhance neovascularization and bone regeneration.
简介
骨再生取决于相关部位的血管生成。本研究旨在探讨自体骨移植混合重组人血管内皮生长因子（rhVEGF）对大鼠下颌骨缺损骨再生的影响。
材料与方法
使用 32 只 Wistar 白化大鼠，我们的实验研究包括 4 组：第 1 组（对照组），缺损为空；第 2 组，仅自体骨移植；第 3 组，明胶海绵加 rhVEGF 应用；第 4 组，自体骨移植加 rhVEGF 应用。术后第 28 天处死大鼠。对新骨再生进行组织学和免疫组织化学分析。
结果
我们的组织学分析表明，与第 1 组和第 2 组相比，第 3 组的新骨再生得到增强。然而，自体骨移植结合 rhVEGF 提供了最佳的结果，伴随着新骨的重塑增加。
结论
根据我们的结果，可以得出结论，自体骨移植结合 rhVEGF 可能增强新血管生成和骨再生。
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