College of Animal Science and Technology, Jilin Provincial Engineering Research Center of Animal Probiotics, Key Lab of Animal Production, Product Quality and Security, Joint Laboratory of Modern Agricultural Technology International Cooperation, Ministry of Education, Jilin Agricultural University, Changchun, China.
College of Life Science, Changchun Sci-Tech University, Changchun, China.
J Fish Dis. 2021 Jan;44(1):11-24. doi: 10.1111/jfd.13262. Epub 2020 Nov 2.
Aeromonas veronii is an important zoonotic and aquatic agent. More and more cases have shown that it has caused huge economic losses in the aquaculture industry in addition to threatening human health. But the reasons for the increasing virulence of A. veronii are still unclear. In order to further understand the reasons for the increased virulence of A. veronii, we conducted a comparative analysis of the genomes of A. veronii with different virulence. The analysis revealed that there are multiple virulence factors, such as those related to fimbriae, flagella, toxins, iron ion uptake systems and type II, type III and type VI secretion systems in the virulent strain TH0426 genome. And comparative analysis showed that there were two complete type III secretion systems (API1 and API2), of which the API2 and iron ion transport system were unique to the TH0426 strain. In addition, TH0426 strain also has unique functional gene clusters, which may play important roles in terms of resisting infection, adapting to different environments and genetic evolution. These particular virulence factors and gene clusters may be the important reasons for the increased virulence. These insights will provide a reference for the study of the pathogenesis of A. veronii.
维氏气单胞菌是一种重要的人畜共患病原体和水生生物。越来越多的病例表明，除了威胁人类健康外，它还对水产养殖业造成了巨大的经济损失。但是，维氏气单胞菌毒力增加的原因仍不清楚。为了进一步了解维氏气单胞菌毒力增加的原因，我们对具有不同毒力的维氏气单胞菌基因组进行了比较分析。分析表明，在强毒株 TH0426 基因组中存在多种毒力因子，如菌毛、鞭毛、毒素、铁离子摄取系统以及 II 型、III 型和 VI 型分泌系统。比较分析表明，TH0426 株中存在两个完整的 III 型分泌系统（API1 和 API2），其中 API2 和铁离子转运系统是 TH0426 株所特有的。此外，TH0426 株还具有独特的功能基因簇，这可能在抵抗感染、适应不同环境和遗传进化方面发挥重要作用。这些特殊的毒力因子和基因簇可能是毒力增加的重要原因。这些研究结果为维氏气单胞菌的发病机制研究提供了参考。
