Department of Pediatrics, Division of Neonatology, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Turkey.
Department of Pediatrics, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Turkey.
Pediatr Pulmonol. 2021 Jan;56(1):274-282. doi: 10.1002/ppul.25125. Epub 2020 Nov 2.
Few data are available concerning normative lung function parameters measured in unsedated neonates.
To evaluate lung function changes in neonates.
In this prospective cohort study, tidal breath parameters were measured using the MasterScreen PAED system and standardized protocols. Measurements were performed on 60 (30 male) term, healthy, unsedated neonates on the postnatal 2nd and 30th days.
Expiratory time (TE; p < .001; Cohen's d = 0.561), exhaled volume to peak tidal expiratory flow (VPTEF; p < .001; Cohen's d = 0.789), minute ventilation (p < .001; Cohen's d = 0.926), tidal volume (VT; p < .001; Cohen's d = 1.835), expiratory flow when 75%, 50%, and 25% of tidal volume remaining in the lungs (TEF75 [p < .001; Cohen's d = 1.070], TEF50 [p < .001; Cohen's d = 0.824], TEF25 [p < .001; Cohen's d = 0.568]), and inspiratory time (Ti; p < .001; Cohen's d = 0.654) were higher on Day 30 compared to Day 2, while time to reach peak tidal expiratory flow to total expiratory time (TPTEF/TE; p = .006; Cohen's d = 0.371), the volume until peak tidal expiratory flow to total expiratory volume (VPTEF/VE; p = .001; Cohen's d = 0.447), and respiration rate (RR; p = .001; Cohen's d = 0.432) were lower, and Ti/TE was unchanged. Positive correlation was observed between length and VT (r = .347; p = .008) on Day 2 and (r = .338; p = .008) on Day 30.
The present study reveals the physiological changes occurring in lung functions in healthy term neonates during the neonatal period.
关于未镇静新生儿的肺功能参数的正常标准数据很少。
评估新生儿的肺功能变化。
在这项前瞻性队列研究中，使用 MasterScreen PAED 系统和标准化方案测量潮气呼吸参数。在出生后第 2 天和第 30 天，对 60 名（30 名男性）足月、健康、未镇静的新生儿进行了测量。
呼气时间（TE；p<0.001；Cohen's d=0.561）、呼气峰流速时的呼出容量（VPTEF；p<0.001；Cohen's d=0.789）、分钟通气量（p<0.001；Cohen's d=0.926）、潮气量（VT；p<0.001；Cohen's d=1.835）、当肺部剩余潮气量的 75%、50%和 25%时的呼气流量（TEF75[p<0.001；Cohen's d=1.070]、TEF50[p<0.001；Cohen's d=0.824]、TEF25[p<0.001；Cohen's d=0.568]）和吸气时间（Ti；p<0.001；Cohen's d=0.654）在第 30 天均高于第 2 天，而达到呼气峰流速的时间与总呼气时间的比值（TPTEF/TE；p=0.006；Cohen's d=0.371）、达到呼气峰流速的容量与总呼气容量的比值（VPTEF/VE；p=0.001；Cohen's d=0.447）和呼吸频率（RR；p=0.001；Cohen's d=0.432）均较低，Ti/TE 无变化。第 2 天和第 30 天均观察到长度与 VT 之间存在正相关（r=0.347；p=0.008）。
本研究揭示了健康足月新生儿在新生儿期肺功能的生理变化。
