Division of Gastroenterology and Hepatology, Tufts Medical Center, Boston, Massachusetts, United States.
Center for Advanced Endoscopy, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States.
Endoscopy. 2021 Sep;53(9):937-940. doi: 10.1055/a-1302-2942. Epub 2021 Jan 18.
The occurrence of false-positive alerts is an important outcome measure in computer-aided colon polyp detection (CADe) studies. However, there is no consensus definition of a false positive in clinical trials evaluating CADe in colonoscopy. We aimed to study the diagnostic performance of CADe based on different threshold definitions for false-positive alerts.
A previously validated CADe system was applied to screening/surveillance colonoscopy videos. Different thresholds for false-positive alerts were defined based on the time an alert box was continuously traced by the system. Primary outcomes were false-positive results and specificity using different threshold definitions of false positive.
62 colonoscopies were analyzed. CADe specificity and accuracy were 93.2 % and 97.8 %, respectively, for a threshold definition of ≥ 0.5 seconds, 98.6 % and 99.5 % for a threshold definition of ≥ 1 second, and 99.8 % and 99.9 % for a threshold definition of ≥ 2 seconds.
Our analysis demonstrated how different threshold definitions of false positive can impact the reported diagnostic performance of CADe for colon polyp detection.
假阳性警报的发生是计算机辅助结肠息肉检测 (CADe) 研究中的一个重要结果衡量标准。然而，在评估结肠镜检查中 CADe 的临床试验中，对于假阳性并没有共识的定义。我们旨在研究基于不同假阳性警报阈值定义的 CADe 的诊断性能。
应用经过验证的 CADe 系统对筛查/监测结肠镜视频进行分析。根据系统连续跟踪警报框的时间，定义不同的假阳性警报阈值。主要结果是使用不同的假阳性阈值定义的假阳性结果和特异性。
共分析了 62 例结肠镜检查。对于阈值定义为≥0.5 秒，CADe 的特异性和准确性分别为 93.2%和 97.8%；对于阈值定义为≥1 秒，特异性和准确性分别为 98.6%和 99.5%；对于阈值定义为≥2 秒，特异性和准确性分别为 99.8%和 99.9%。
我们的分析表明，不同的假阳性阈值定义如何影响 CADe 对结肠息肉检测的报告诊断性能。
